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- W2108156722 abstract "Platelet-derived growth factor (PDGF) is one of the most thoroughly studied proteins in the body. Research has progressively highlighted the role of PDGF during wound healing and in the bone repair cascade. This research has resulted in FDA approval of 2 products containing a recombinant version of the protein, rhPDGF-BB, for treating chronic diabetic foot ulcers and periodontal bone defects. This article reviews the applicable basic science and mechanisms of action of PDGF, with attention to the increasingly defined role of rhPDGF-BB in initiating bone regeneration. The most recent data from prospective clinical trials evaluating the use of rhPDGF-BB in combination with beta tricalcium phosphate as a substitute for autogenous bone graft in hindfoot and ankle arthrodesis are also summarized." @default.
- W2108156722 created "2016-06-24" @default.
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- W2108156722 date "2010-12-01" @default.
- W2108156722 modified "2023-09-30" @default.
- W2108156722 title "The Evolution of rhPDGF-BB in Musculoskeletal Repair and its Role in Foot and Ankle Fusion Surgery" @default.
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- W2108156722 doi "https://doi.org/10.1016/j.fcl.2010.07.001" @default.
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