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- W2108172661 abstract "Gene amplification occurs at high frequency in transformed cells (10−3–10−5), but is undetectable in normal diploid fibroblasts (<10−9). This study examines whether alterations of one or both p53 alleles were sufficient to allow gene amplification to occur. Cells retaining one wild-type p53 allele mimicked the behavior of primary diploid cells: they arrested growth in the presence of drug and failed to demonstrate amplification. Cells losing the second p53 allele failed to arrest when placed in drug and displayed the ability to amplify at a high frequency. Thus, loss of wild-type p53 may lead to amplification, possibly caused by changes in cell cycle progression. Other determinants can by-pass this p53 function, however, since tumor cells with wild-type p53 have the ability to amplify genes." @default.
- W2108172661 created "2016-06-24" @default.
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- W2108172661 date "1992-09-01" @default.
- W2108172661 modified "2023-10-12" @default.
- W2108172661 title "Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53" @default.
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- W2108172661 doi "https://doi.org/10.1016/0092-8674(92)90243-6" @default.
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