FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108173600> ?p ?o ?g. }

• W2108173600 endingPage "52" @default.
• W2108173600 startingPage "52" @default.
• W2108173600 abstract "Purpose. We investigated elemental strontium and/or bisphosphonate drug incorporation upon the compositional and biomechanical properties of vertebral bone, in a rat model of Osteoporosis secondary to ovariectomy. Methods. Six month old female rats were ovariectomized (OVX) and divided into untreated OVX-Vehicle, OVX-RIS (Risedronate bisphosphonate [BP] treated), OVX-SrR (Strontium Ranelate [Protos®] treated), combination OVX-RIS+SrR, and sham-operated controls. After 16 weeks of treatment, rats were euthanized and lumbar vertebra were dissected. Micro-Computed Tomography (micro-CT), Electron Probe Micro-Analysis (EPMA), mechanical testing in compression and nano-indentation testing were then undertaken to evaluate bone morphometry, elemental composition, material properties and strength. Results. Bone Volume was significantly reduced in the OVX-Vehicle (133±10mm3) compared with OVX-RIS (169±22mm3), OVX-SrR (145±2mm3), and OVX-RIS+SrR (172±8mm3). EPMA mapped elemental Sr deposition to the periosteal surface of cortical bone (50-100 µm thick), endosteal trabecular surfaces (20 µm thick), as well as to both vertebral growth plates. The atomic ratios of (Ca+Sr)/P were significantly reduced with SrR treatment (2.4%-6.6%), indicating Sr incorporation into bone mineral. No significant differences were measured in vertebral bone reduced modulus by nano-indentation. Conversely, all BP-dosed groups had significantly increased structural bone strength. Conclusions. Thus, we conclude that BP drugs dominate the conservation of trabecular geometry and structural strength in OP rats, whereas Sr drugs likely influence bone volume and material composition locally. &#x0D; &#x0D; This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page." @default.
• W2108173600 created "2016-06-24" @default.
• W2108173600 creator A5027355359 @default.
• W2108173600 creator A5053910564 @default.
• W2108173600 creator A5063052584 @default.
• W2108173600 creator A5071767904 @default.
• W2108173600 creator A5085137473 @default.
• W2108173600 date "2013-01-28" @default.
• W2108173600 modified "2023-09-27" @default.
• W2108173600 title "Compositional and Material Properties of Rat Bone after Bisphosphonate and/or Strontium Ranelate Drug Treatment" @default.
• W2108173600 cites W1521780264 @default.
• W2108173600 cites W1526826623 @default.
• W2108173600 cites W1964023148 @default.
• W2108173600 cites W1965075574 @default.
• W2108173600 cites W1988541434 @default.
• W2108173600 cites W2004189107 @default.
• W2108173600 cites W2005942823 @default.
• W2108173600 cites W2017796855 @default.
• W2108173600 cites W2020909365 @default.
• W2108173600 cites W2026090531 @default.
• W2108173600 cites W2029064643 @default.
• W2108173600 cites W2037782177 @default.
• W2108173600 cites W2040743937 @default.
• W2108173600 cites W2046164606 @default.
• W2108173600 cites W2061272816 @default.
• W2108173600 cites W2066749771 @default.
• W2108173600 cites W2078470916 @default.
• W2108173600 cites W2079787452 @default.
• W2108173600 cites W2083453693 @default.
• W2108173600 cites W2109176285 @default.
• W2108173600 cites W2119062112 @default.
• W2108173600 cites W2136302930 @default.
• W2108173600 cites W2143899570 @default.
• W2108173600 cites W2157956984 @default.
• W2108173600 cites W2169251377 @default.
• W2108173600 cites W2333102461 @default.
• W2108173600 cites W2624963411 @default.
• W2108173600 doi "https://doi.org/10.18433/j3c59h" @default.
• W2108173600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23683605" @default.
• W2108173600 hasPublicationYear "2013" @default.
• W2108173600 type Work @default.
• W2108173600 sameAs 2108173600 @default.
• W2108173600 citedByCount "17" @default.
• W2108173600 countsByYear W21081736002013 @default.
• W2108173600 countsByYear W21081736002014 @default.
• W2108173600 countsByYear W21081736002015 @default.
• W2108173600 countsByYear W21081736002016 @default.
• W2108173600 countsByYear W21081736002017 @default.
• W2108173600 countsByYear W21081736002018 @default.
• W2108173600 countsByYear W21081736002020 @default.
• W2108173600 countsByYear W21081736002022 @default.
• W2108173600 crossrefType "journal-article" @default.
• W2108173600 hasAuthorship W2108173600A5027355359 @default.
• W2108173600 hasAuthorship W2108173600A5053910564 @default.
• W2108173600 hasAuthorship W2108173600A5063052584 @default.
• W2108173600 hasAuthorship W2108173600A5071767904 @default.
• W2108173600 hasAuthorship W2108173600A5085137473 @default.
• W2108173600 hasBestOaLocation W21081736001 @default.
• W2108173600 hasConcept C126322002 @default.
• W2108173600 hasConcept C134018914 @default.
• W2108173600 hasConcept C138411078 @default.
• W2108173600 hasConcept C178790620 @default.
• W2108173600 hasConcept C185592680 @default.
• W2108173600 hasConcept C199289684 @default.
• W2108173600 hasConcept C2776541429 @default.
• W2108173600 hasConcept C2776594446 @default.
• W2108173600 hasConcept C2776886416 @default.
• W2108173600 hasConcept C2777164284 @default.
• W2108173600 hasConcept C518915863 @default.
• W2108173600 hasConcept C71924100 @default.
• W2108173600 hasConcept C8264082 @default.
• W2108173600 hasConceptScore W2108173600C126322002 @default.
• W2108173600 hasConceptScore W2108173600C134018914 @default.
• W2108173600 hasConceptScore W2108173600C138411078 @default.
• W2108173600 hasConceptScore W2108173600C178790620 @default.
• W2108173600 hasConceptScore W2108173600C185592680 @default.
• W2108173600 hasConceptScore W2108173600C199289684 @default.
• W2108173600 hasConceptScore W2108173600C2776541429 @default.
• W2108173600 hasConceptScore W2108173600C2776594446 @default.
• W2108173600 hasConceptScore W2108173600C2776886416 @default.
• W2108173600 hasConceptScore W2108173600C2777164284 @default.
• W2108173600 hasConceptScore W2108173600C518915863 @default.
• W2108173600 hasConceptScore W2108173600C71924100 @default.
• W2108173600 hasConceptScore W2108173600C8264082 @default.
• W2108173600 hasIssue "1" @default.
• W2108173600 hasLocation W21081736001 @default.
• W2108173600 hasLocation W21081736002 @default.
• W2108173600 hasLocation W21081736003 @default.
• W2108173600 hasOpenAccess W2108173600 @default.
• W2108173600 hasPrimaryLocation W21081736001 @default.
• W2108173600 hasRelatedWork W1981503997 @default.
• W2108173600 hasRelatedWork W1995863458 @default.
• W2108173600 hasRelatedWork W2009754781 @default.
• W2108173600 hasRelatedWork W2018867005 @default.
• W2108173600 hasRelatedWork W2030512885 @default.
• W2108173600 hasRelatedWork W2071078849 @default.
• W2108173600 hasRelatedWork W2085671461 @default.
• W2108173600 hasRelatedWork W2086610965 @default.

• next