Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108174511> ?p ?o ?g. }
- W2108174511 endingPage "66" @default.
- W2108174511 startingPage "27" @default.
- W2108174511 abstract "Host defence peptides are a conserved component of the innate immune response in all complex life forms. In humans, the major classes of host defence peptides include the α- and β-defensins and the cathelicidin, hCAP-18/LL-37. These peptides are expressed in the granules of neutrophils and by a wide variety of tissue types. They have many roles in the immune response including both indirect and direct antimicrobial activity, the ability to act as chemokines as well as induce chemokine production leading to recruitment of leukocytes to the site of infection, the promotion of wound healing and an ability to modulate adaptive immunity. It appears that many of these properties are mediated though direct interaction of peptides with the cells of the innate immune response including monocytes, dendritic cells, T cells and epithelial cells. The importance of these peptides in immune responses has been demonstrated since animals defective in the expression of certain host defence peptides showgreater susceptibility to bacterial infections. In the very few instances in which human patients have been demonstrated to have defective host defence peptide expression, these individuals suffer from frequent infections. Although studies of the immunomodulatory properties of these peptides are in their infancy, there is a growing body of evidence suggesting that the immunomodulatory properties of these small, naturally occurring molecules might be harnessed for development as novel therapeutic agents." @default.
- W2108174511 created "2016-06-24" @default.
- W2108174511 creator A5010363328 @default.
- W2108174511 creator A5048929131 @default.
- W2108174511 creator A5066530115 @default.
- W2108174511 date "2006-01-01" @default.
- W2108174511 modified "2023-10-16" @default.
- W2108174511 title "Immunomodulatory Properties of Defensins and Cathelicidins" @default.
- W2108174511 cites W1488377901 @default.
- W2108174511 cites W1500925296 @default.
- W2108174511 cites W1521868200 @default.
- W2108174511 cites W1558372199 @default.
- W2108174511 cites W1571292455 @default.
- W2108174511 cites W1576577682 @default.
- W2108174511 cites W1578768687 @default.
- W2108174511 cites W1589692813 @default.
- W2108174511 cites W1591492731 @default.
- W2108174511 cites W1602448053 @default.
- W2108174511 cites W1608815389 @default.
- W2108174511 cites W1630083155 @default.
- W2108174511 cites W1673257055 @default.
- W2108174511 cites W1749241146 @default.
- W2108174511 cites W1789475526 @default.
- W2108174511 cites W1887368236 @default.
- W2108174511 cites W1921818371 @default.
- W2108174511 cites W1943160106 @default.
- W2108174511 cites W1964567654 @default.
- W2108174511 cites W1964703096 @default.
- W2108174511 cites W1964758221 @default.
- W2108174511 cites W1965432550 @default.
- W2108174511 cites W1966446054 @default.
- W2108174511 cites W1967251205 @default.
- W2108174511 cites W1967638463 @default.
- W2108174511 cites W1973597588 @default.
- W2108174511 cites W1974318626 @default.
- W2108174511 cites W1979138020 @default.
- W2108174511 cites W1983987058 @default.
- W2108174511 cites W1984287836 @default.
- W2108174511 cites W1985766571 @default.
- W2108174511 cites W1991625690 @default.
- W2108174511 cites W1997683664 @default.
- W2108174511 cites W2000375475 @default.
- W2108174511 cites W2001740313 @default.
- W2108174511 cites W2004122893 @default.
- W2108174511 cites W2004654708 @default.
- W2108174511 cites W2011807378 @default.
- W2108174511 cites W2013767004 @default.
- W2108174511 cites W2014055037 @default.
- W2108174511 cites W2020668335 @default.
- W2108174511 cites W2022577580 @default.
- W2108174511 cites W2022722340 @default.
- W2108174511 cites W2023893212 @default.
- W2108174511 cites W2027230853 @default.
- W2108174511 cites W2027243972 @default.
- W2108174511 cites W2029727629 @default.
- W2108174511 cites W2032685954 @default.
- W2108174511 cites W2035286882 @default.
- W2108174511 cites W2038121569 @default.
- W2108174511 cites W2038307426 @default.
- W2108174511 cites W2040597252 @default.
- W2108174511 cites W2042116386 @default.
- W2108174511 cites W2042481588 @default.
- W2108174511 cites W2044384508 @default.
- W2108174511 cites W2046438451 @default.
- W2108174511 cites W2047599457 @default.
- W2108174511 cites W2048389635 @default.
- W2108174511 cites W2049240593 @default.
- W2108174511 cites W2051899717 @default.
- W2108174511 cites W2053044114 @default.
- W2108174511 cites W2055856930 @default.
- W2108174511 cites W2056556207 @default.
- W2108174511 cites W2058223359 @default.
- W2108174511 cites W2059425933 @default.
- W2108174511 cites W2060300255 @default.
- W2108174511 cites W2061411768 @default.
- W2108174511 cites W2062813847 @default.
- W2108174511 cites W2069051729 @default.
- W2108174511 cites W2069492069 @default.
- W2108174511 cites W2069637967 @default.
- W2108174511 cites W2071254871 @default.
- W2108174511 cites W2072432297 @default.
- W2108174511 cites W2075328959 @default.
- W2108174511 cites W2076513631 @default.
- W2108174511 cites W2077604052 @default.
- W2108174511 cites W2078781814 @default.
- W2108174511 cites W2079884351 @default.
- W2108174511 cites W2080267955 @default.
- W2108174511 cites W2081094127 @default.
- W2108174511 cites W2081347555 @default.
- W2108174511 cites W2081497189 @default.
- W2108174511 cites W2083772421 @default.
- W2108174511 cites W2083845392 @default.
- W2108174511 cites W2084177740 @default.
- W2108174511 cites W2084263146 @default.
- W2108174511 cites W2085269931 @default.
- W2108174511 cites W2085486913 @default.
- W2108174511 cites W2085793178 @default.
- W2108174511 cites W2087976424 @default.