FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108175078> ?p ?o ?g. }

• W2108175078 endingPage "679" @default.
• W2108175078 startingPage "675" @default.
• W2108175078 abstract "We have examined the effects of the seco-steroid hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on membrane phosphoinositide metabolism, protein kinase C (PKC) activation and influx of extracellular Ca2+ in chick-embryo muscle-cell (myoblast) cultures. At physiological concentrations, the hormone induces a rapid (15 s) and transient release of inositol triphosphate (InsP3) and diacylglycerol (DAG). InsP3 release is maximal at 60 s (80% above controls) and then declines. The effects of 1,25(OH)2D3 on InsP3 production exhibited specificity, as 25-hydroxy-vitamin D3 and 24,25-dihydroxy-vitamin D3 did not alter myoblast InsP3 levels. The stimulation of DAG is biphasic, with peaks at 60 s (+105%) and 5 min (+700%). The second phase of DAG release is not associated with changes in InsP3. 1,25(OH)2D3 induces a rapid (within 60 s) accumulation of InsP2, and its effect on InsP is delayed (120 s). The hormone rapidly activates myoblast PKC, with maximal translocation of activity from the cytosol to the cell membrane occurring at 60 s. Myoblast 45Ca uptake significantly increases within 30 s of exposure to 1,25(OH)2D3. The response is time- (0.5-10 min) and dose- (1 pM-10 nM) dependent. The effects of the hormone are mimicked by the Ca(2+)-channel agonist Bay K 8644 and are effectively suppressed by nifedipine and extracellular EGTA. The results suggest that the rapid non-genomic actions of 1,25(OH)2D3 in myoblasts involve second-messenger systems associated with the generation of InsP3 and DAG and regulation of Ca2+ fluxes through voltage-operated channels." @default.
• W2108175078 created "2016-06-24" @default.
• W2108175078 creator A5046394920 @default.
• W2108175078 creator A5059268113 @default.
• W2108175078 creator A5062612045 @default.
• W2108175078 date "1993-02-01" @default.
• W2108175078 modified "2023-10-15" @default.
• W2108175078 title "Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3" @default.
• W2108175078 cites W1045314443 @default.
• W2108175078 cites W1537090264 @default.
• W2108175078 cites W1576923208 @default.
• W2108175078 cites W1584929737 @default.
• W2108175078 cites W1775749144 @default.
• W2108175078 cites W1802980406 @default.
• W2108175078 cites W194629505 @default.
• W2108175078 cites W1963625050 @default.
• W2108175078 cites W1973237558 @default.
• W2108175078 cites W1979893127 @default.
• W2108175078 cites W1993513591 @default.
• W2108175078 cites W1993612650 @default.
• W2108175078 cites W1997442781 @default.
• W2108175078 cites W2008278018 @default.
• W2108175078 cites W2009935511 @default.
• W2108175078 cites W2010880470 @default.
• W2108175078 cites W2016219644 @default.
• W2108175078 cites W2017733935 @default.
• W2108175078 cites W2035249816 @default.
• W2108175078 cites W2036152484 @default.
• W2108175078 cites W2054362917 @default.
• W2108175078 cites W2061628918 @default.
• W2108175078 cites W2067864810 @default.
• W2108175078 cites W2069151784 @default.
• W2108175078 cites W2076362911 @default.
• W2108175078 cites W2078375696 @default.
• W2108175078 cites W2079230724 @default.
• W2108175078 cites W2081094274 @default.
• W2108175078 cites W2083869788 @default.
• W2108175078 cites W2090464853 @default.
• W2108175078 cites W2093641160 @default.
• W2108175078 cites W2120585687 @default.
• W2108175078 cites W2136189765 @default.
• W2108175078 cites W2149637850 @default.
• W2108175078 cites W2154061155 @default.
• W2108175078 cites W2160014306 @default.
• W2108175078 cites W2168526937 @default.
• W2108175078 cites W2199766646 @default.
• W2108175078 cites W2488136515 @default.
• W2108175078 doi "https://doi.org/10.1042/bj2890675" @default.
• W2108175078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1132228" @default.
• W2108175078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8382046" @default.
• W2108175078 hasPublicationYear "1993" @default.
• W2108175078 type Work @default.
• W2108175078 sameAs 2108175078 @default.
• W2108175078 citedByCount "112" @default.
• W2108175078 countsByYear W21081750782012 @default.
• W2108175078 countsByYear W21081750782013 @default.
• W2108175078 countsByYear W21081750782014 @default.
• W2108175078 countsByYear W21081750782015 @default.
• W2108175078 countsByYear W21081750782017 @default.
• W2108175078 countsByYear W21081750782018 @default.
• W2108175078 countsByYear W21081750782019 @default.
• W2108175078 countsByYear W21081750782020 @default.
• W2108175078 countsByYear W21081750782021 @default.
• W2108175078 crossrefType "journal-article" @default.
• W2108175078 hasAuthorship W2108175078A5046394920 @default.
• W2108175078 hasAuthorship W2108175078A5059268113 @default.
• W2108175078 hasAuthorship W2108175078A5062612045 @default.
• W2108175078 hasBestOaLocation W21081750782 @default.
• W2108175078 hasConcept C126322002 @default.
• W2108175078 hasConcept C134018914 @default.
• W2108175078 hasConcept C163235415 @default.
• W2108175078 hasConcept C170493617 @default.
• W2108175078 hasConcept C181199279 @default.
• W2108175078 hasConcept C184235292 @default.
• W2108175078 hasConcept C185592680 @default.
• W2108175078 hasConcept C195794163 @default.
• W2108175078 hasConcept C207200792 @default.
• W2108175078 hasConcept C2777427919 @default.
• W2108175078 hasConcept C2777658833 @default.
• W2108175078 hasConcept C2781387506 @default.
• W2108175078 hasConcept C28406088 @default.
• W2108175078 hasConcept C36020004 @default.
• W2108175078 hasConcept C519063684 @default.
• W2108175078 hasConcept C55493867 @default.
• W2108175078 hasConcept C71924100 @default.
• W2108175078 hasConcept C79879829 @default.
• W2108175078 hasConcept C86803240 @default.
• W2108175078 hasConcept C98539663 @default.
• W2108175078 hasConceptScore W2108175078C126322002 @default.
• W2108175078 hasConceptScore W2108175078C134018914 @default.
• W2108175078 hasConceptScore W2108175078C163235415 @default.
• W2108175078 hasConceptScore W2108175078C170493617 @default.
• W2108175078 hasConceptScore W2108175078C181199279 @default.
• W2108175078 hasConceptScore W2108175078C184235292 @default.
• W2108175078 hasConceptScore W2108175078C185592680 @default.
• W2108175078 hasConceptScore W2108175078C195794163 @default.
• W2108175078 hasConceptScore W2108175078C207200792 @default.
• W2108175078 hasConceptScore W2108175078C2777427919 @default.

• next