FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108178211> ?p ?o ?g. }

• W2108178211 endingPage "1099" @default.
• W2108178211 startingPage "1089" @default.
• W2108178211 abstract "Reverse genetics was used to develop a two-component, trivalent live attenuated vaccine against human parainfluenza virus type 3 (HPIV3) and respiratory syncytial virus (RSV) subgroups A and B. The backbone for each of the two components of this vaccine was the attenuated recombinant bovine/human PIV3 (rB/HPIV3), a recombinant BPIV3 in which the bovine HN and F protective antigens are replaced by their HPIV3 counterparts (48). This chimera retains the well-characterized host range attenuation phenotype of BPIV3, which appears to be appropriate for immunization of young infants. The open reading frames (ORFs) for the G and F major protective antigens of RSV subgroup A and B were each placed under the control of PIV3 transcription signals and inserted individually or in homologous pairs as supernumerary genes in the promoter proximal position of rB/HPIV3. The level of replication of rB/HPIV3-RSV chimeric viruses in the respiratory tract of rhesus monkeys was similar to that of their parent virus rB/HPIV3, and each of the chimeras induced a robust immune response to both RSV and HPIV3. RSV-neutralizing antibody titers induced by rB/HPIV3-RSV chimeric viruses were equivalent to those induced by infection with wild-type RSV, and HPIV3-specific antibody responses were similar to, or slightly less than, after infection with the rB/HPIV3 vector itself. This study describes a novel vaccine strategy against RSV in which vaccine viruses with a common attenuated backbone, specifically rB/HPIV3 derivatives expressing the G and/or F major protective antigens of RSV subgroup A and of RSV subgroup B, are used to immunize by the intranasal route against RSV and HPIV3, which are the first and second most important viral agents of pediatric respiratory tract disease worldwide." @default.
• W2108178211 created "2016-06-24" @default.
• W2108178211 creator A5027582911 @default.
• W2108178211 creator A5029814162 @default.
• W2108178211 creator A5062733502 @default.
• W2108178211 creator A5070578264 @default.
• W2108178211 creator A5087874713 @default.
• W2108178211 creator A5090982760 @default.
• W2108178211 creator A5090780931 @default.
• W2108178211 date "2002-02-01" @default.
• W2108178211 modified "2023-10-15" @default.
• W2108178211 title "Mucosal Immunization of Rhesus Monkeys against Respiratory Syncytial Virus Subgroups A and B and Human Parainfluenza Virus Type 3 by Using a Live cDNA-Derived Vaccine Based on a Host Range-Attenuated Bovine Parainfluenza Virus Type 3 Vector Backbone" @default.
• W2108178211 cites W1502226011 @default.
• W2108178211 cites W1530867604 @default.
• W2108178211 cites W1533200296 @default.
• W2108178211 cites W1566141704 @default.
• W2108178211 cites W1578183550 @default.
• W2108178211 cites W1595049216 @default.
• W2108178211 cites W1605220975 @default.
• W2108178211 cites W162437703 @default.
• W2108178211 cites W1784291848 @default.
• W2108178211 cites W1812581977 @default.
• W2108178211 cites W1952265349 @default.
• W2108178211 cites W1966437202 @default.
• W2108178211 cites W1971781162 @default.
• W2108178211 cites W1978070251 @default.
• W2108178211 cites W1980436917 @default.
• W2108178211 cites W1985366380 @default.
• W2108178211 cites W1997745179 @default.
• W2108178211 cites W1998423649 @default.
• W2108178211 cites W2002985673 @default.
• W2108178211 cites W2003182642 @default.
• W2108178211 cites W2009239426 @default.
• W2108178211 cites W2010946566 @default.
• W2108178211 cites W2015929165 @default.
• W2108178211 cites W2016017622 @default.
• W2108178211 cites W2016351081 @default.
• W2108178211 cites W2017468106 @default.
• W2108178211 cites W2022453215 @default.
• W2108178211 cites W2023719818 @default.
• W2108178211 cites W2026190929 @default.
• W2108178211 cites W2027729255 @default.
• W2108178211 cites W2028532590 @default.
• W2108178211 cites W2052501023 @default.
• W2108178211 cites W2056574647 @default.
• W2108178211 cites W2056628284 @default.
• W2108178211 cites W2059653901 @default.
• W2108178211 cites W2061647921 @default.
• W2108178211 cites W2072881891 @default.
• W2108178211 cites W2077290707 @default.
• W2108178211 cites W2077567489 @default.
• W2108178211 cites W2089707858 @default.
• W2108178211 cites W2098213772 @default.
• W2108178211 cites W2104526141 @default.
• W2108178211 cites W2105684141 @default.
• W2108178211 cites W2106953210 @default.
• W2108178211 cites W2115649182 @default.
• W2108178211 cites W2122557423 @default.
• W2108178211 cites W2123817481 @default.
• W2108178211 cites W2125115617 @default.
• W2108178211 cites W2131013625 @default.
• W2108178211 cites W2133963352 @default.
• W2108178211 cites W2137012275 @default.
• W2108178211 cites W2139929901 @default.
• W2108178211 cites W2156621380 @default.
• W2108178211 cites W2157395311 @default.
• W2108178211 cites W2158442131 @default.
• W2108178211 cites W2159213937 @default.
• W2108178211 cites W2159482780 @default.
• W2108178211 cites W2168026897 @default.
• W2108178211 cites W2168544733 @default.
• W2108178211 cites W2171134740 @default.
• W2108178211 cites W2175169174 @default.
• W2108178211 cites W336954882 @default.
• W2108178211 cites W4244766688 @default.
• W2108178211 cites W4292315834 @default.
• W2108178211 cites W4302594490 @default.
• W2108178211 doi "https://doi.org/10.1128/jvi.76.3.1089-1099.2002" @default.
• W2108178211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/135799" @default.
• W2108178211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11773385" @default.
• W2108178211 hasPublicationYear "2002" @default.
• W2108178211 type Work @default.
• W2108178211 sameAs 2108178211 @default.
• W2108178211 citedByCount "76" @default.
• W2108178211 countsByYear W21081782112012 @default.
• W2108178211 countsByYear W21081782112013 @default.
• W2108178211 countsByYear W21081782112014 @default.
• W2108178211 countsByYear W21081782112015 @default.
• W2108178211 countsByYear W21081782112016 @default.
• W2108178211 countsByYear W21081782112020 @default.
• W2108178211 crossrefType "journal-article" @default.
• W2108178211 hasAuthorship W2108178211A5027582911 @default.
• W2108178211 hasAuthorship W2108178211A5029814162 @default.
• W2108178211 hasAuthorship W2108178211A5062733502 @default.
• W2108178211 hasAuthorship W2108178211A5070578264 @default.
• W2108178211 hasAuthorship W2108178211A5087874713 @default.
• W2108178211 hasAuthorship W2108178211A5090780931 @default.
• W2108178211 hasAuthorship W2108178211A5090982760 @default.

• next