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- W2108183446 abstract "Tumor invasion and metastasis are complex, multistep processes involving cellular detachment from primary sites, adhesion to extracellular/cellular matrices, local proteolytic degradation of matrix proteins and migration. Several proteases are involved in these complex processes. Besides matrix metalloproteases (MMP's) (Liotta and StetlerStevenson, 1990) and the urokinase-type plasminogen activator (u-PA) (Schmidt et al 1992), cathepsin B (cat B) (Sloane et al. 1990) is considered to play important roles in the different destructive occurrences. Besides direct proteolysis of components of the basement membrane and extracellular matrix, cat B participates in enzyme activation cascades, including other cathepsins and uPA (Kobayashi et al 1991). To block not only the catalytic activity of the cysteine protease cat B (e.g. by anticatalytical antibodies), the osteosarcoma cell line MNNG/HOS was stably transfected with antisense cat B constructs, resulting in direct suppression of cat B expression in the tumor cells. We selected cell clones with the lowest enzyme expression to functionally characterize them in invitro assays of invasion and motility, compared with the parental cell line MNNG/HOS." @default.
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- W2108183446 date "2006-03-05" @default.
- W2108183446 modified "2023-09-27" @default.
- W2108183446 title "Antisense Inhibition of Cathepsin Bina Human Osteosarcoma Cell Line" @default.
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- W2108183446 doi "https://doi.org/10.1007/0-306-46826-3_44" @default.
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