FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108185219> ?p ?o ?g. }

• W2108185219 endingPage "465" @default.
• W2108185219 startingPage "462" @default.
• W2108185219 abstract "Conversion to sirolimus from calcineurin inhibitor- (CNI), azathioprine- (AZA) and mycophenolate-based regimens reduces the risk of development of squamous cell carcinoma of the skin (SCC) in kidney transplant recipients (KTRs). Sirolimus conversion may also be protective by permitting beneficial changes in immune phenotype. It is not known how sirolimus will affect immune phenotype in KTRs with SCC.Thirty-two KTRs with SCC were enrolled into this single-blinded randomized study and 13 KTRs randomized to sirolimus (4-10 ng/mL) and prednisolone 5 mg/day.Six-month post conversion to sirolimus FOXP3(+) CD127(low)CD25(high)CD69(-), the number of T cells (putative Treg) increased significantly (P = 0.008). Natural killer (NK) and CD56(bright) NK cells also increased significantly (P = 0.039 and 0.02). T-cell number only significantly increased in those KTRs where CNI was ceased as part of the conversion to mammalian target of rapamycin inhibitors (mTORi's) (P = 0.031) implying CNI cessation rather than mTORi initiation induced an increase in T-cell number. Increases in the NK cell number was only significant in those KTRs where AZA was ceased (P = 0.040), implying AZA cessation rather than mTORi initiation caused the NK cell number to increase. At 6 months, sirolimus conversion reduces new SCC/year, rate ratio 0.49 (95%CI: 0.15-1.63), P = 0.276. On therapy analysis and intention-to-treat analysis over 24 months, the rate ratios were 0.84 and 0.87, respectively, and did not reach significance.Conversion to mTORi from CNI may reveal a pre-existing high Treg phenotype by unmasking CNI inhibition of FOXP3 expression. Cessation of AZA leads to increased NK cell number. High FOXP3(+) T-cell number on conversion to mTORi may predict those KTRs who continue to accrue SCC." @default.
• W2108185219 created "2016-06-24" @default.
• W2108185219 creator A5012861707 @default.
• W2108185219 creator A5043842591 @default.
• W2108185219 creator A5050506872 @default.
• W2108185219 creator A5054080684 @default.
• W2108185219 date "2012-12-07" @default.
• W2108185219 modified "2023-10-13" @default.
• W2108185219 title "Conversion to sirolimus in kidney transplant recipients with squamous cell cancer and changes in immune phenotype" @default.
• W2108185219 cites W1596082572 @default.
• W2108185219 cites W1908004193 @default.
• W2108185219 cites W1968462479 @default.
• W2108185219 cites W1969510397 @default.
• W2108185219 cites W1989265870 @default.
• W2108185219 cites W1989928855 @default.
• W2108185219 cites W2026351725 @default.
• W2108185219 cites W2026569756 @default.
• W2108185219 cites W2046753653 @default.
• W2108185219 cites W2059257410 @default.
• W2108185219 cites W2083611746 @default.
• W2108185219 cites W2119422390 @default.
• W2108185219 cites W2119861401 @default.
• W2108185219 cites W2121259576 @default.
• W2108185219 cites W2142288396 @default.
• W2108185219 cites W2154037696 @default.
• W2108185219 cites W2164194790 @default.
• W2108185219 cites W2333126124 @default.
• W2108185219 cites W2811157820 @default.
• W2108185219 doi "https://doi.org/10.1093/ndt/gfs474" @default.
• W2108185219 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3572772" @default.
• W2108185219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23223314" @default.
• W2108185219 hasPublicationYear "2012" @default.
• W2108185219 type Work @default.
• W2108185219 sameAs 2108185219 @default.
• W2108185219 citedByCount "25" @default.
• W2108185219 countsByYear W21081852192013 @default.
• W2108185219 countsByYear W21081852192014 @default.
• W2108185219 countsByYear W21081852192015 @default.
• W2108185219 countsByYear W21081852192016 @default.
• W2108185219 countsByYear W21081852192017 @default.
• W2108185219 countsByYear W21081852192018 @default.
• W2108185219 countsByYear W21081852192019 @default.
• W2108185219 countsByYear W21081852192020 @default.
• W2108185219 countsByYear W21081852192022 @default.
• W2108185219 crossrefType "journal-article" @default.
• W2108185219 hasAuthorship W2108185219A5012861707 @default.
• W2108185219 hasAuthorship W2108185219A5043842591 @default.
• W2108185219 hasAuthorship W2108185219A5050506872 @default.
• W2108185219 hasAuthorship W2108185219A5054080684 @default.
• W2108185219 hasBestOaLocation W21081852191 @default.
• W2108185219 hasConcept C126322002 @default.
• W2108185219 hasConcept C126894567 @default.
• W2108185219 hasConcept C128057223 @default.
• W2108185219 hasConcept C203014093 @default.
• W2108185219 hasConcept C2776760755 @default.
• W2108185219 hasConcept C2777921159 @default.
• W2108185219 hasConcept C2779134260 @default.
• W2108185219 hasConcept C2779727006 @default.
• W2108185219 hasConcept C2780252810 @default.
• W2108185219 hasConcept C2780303639 @default.
• W2108185219 hasConcept C2911091166 @default.
• W2108185219 hasConcept C71924100 @default.
• W2108185219 hasConcept C8891405 @default.
• W2108185219 hasConcept C90924648 @default.
• W2108185219 hasConceptScore W2108185219C126322002 @default.
• W2108185219 hasConceptScore W2108185219C126894567 @default.
• W2108185219 hasConceptScore W2108185219C128057223 @default.
• W2108185219 hasConceptScore W2108185219C203014093 @default.
• W2108185219 hasConceptScore W2108185219C2776760755 @default.
• W2108185219 hasConceptScore W2108185219C2777921159 @default.
• W2108185219 hasConceptScore W2108185219C2779134260 @default.
• W2108185219 hasConceptScore W2108185219C2779727006 @default.
• W2108185219 hasConceptScore W2108185219C2780252810 @default.
• W2108185219 hasConceptScore W2108185219C2780303639 @default.
• W2108185219 hasConceptScore W2108185219C2911091166 @default.
• W2108185219 hasConceptScore W2108185219C71924100 @default.
• W2108185219 hasConceptScore W2108185219C8891405 @default.
• W2108185219 hasConceptScore W2108185219C90924648 @default.
• W2108185219 hasIssue "2" @default.
• W2108185219 hasLocation W21081852191 @default.
• W2108185219 hasLocation W21081852192 @default.
• W2108185219 hasLocation W21081852193 @default.
• W2108185219 hasLocation W21081852194 @default.
• W2108185219 hasLocation W21081852195 @default.
• W2108185219 hasOpenAccess W2108185219 @default.
• W2108185219 hasPrimaryLocation W21081852191 @default.
• W2108185219 hasRelatedWork W1515890975 @default.
• W2108185219 hasRelatedWork W171560159 @default.
• W2108185219 hasRelatedWork W1993853244 @default.
• W2108185219 hasRelatedWork W2064796437 @default.
• W2108185219 hasRelatedWork W2130219955 @default.
• W2108185219 hasRelatedWork W2286262296 @default.
• W2108185219 hasRelatedWork W2328505765 @default.
• W2108185219 hasRelatedWork W2794666377 @default.
• W2108185219 hasRelatedWork W4240745173 @default.
• W2108185219 hasRelatedWork W4385580458 @default.
• W2108185219 hasVolume "28" @default.
• W2108185219 isParatext "false" @default.

• next