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- W2108185565 abstract "A wide variety of signaling molecules produced by bacteria may influence physiology of neighboring microorganisms. Indole, a small molecule secreted by bacteria is known to control growth, physiology as well as biofilm formation in various bacteria. Effects of indole on eukaryotic microorganisms are not known. The objective of this study was to analyze response of Candida albicans, commensal yeast of the humans, to indole. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of indole for the growth of C. albicans was studied as per CLSI guidelines. Effect of indole on morphogenesis and adhesion was analyzed by using microplate based standard methodologies. Activity of indole on biofilm development and mature biofilms was studied in an in vitro biofilm model using XTT-metabolic assay and microscopic observations. Indole exhibited fungistatic as well as fungicidal properties to inhibit planktonic and biofilm growth in two strains of C. albicans. Interestingly, the inhibitory effects were obtained at concentrations which may exist in vivo. Indole prevented serum induced filamentous growth at concentrations lower than the growth inhibitory concentration. Inhibition of growth, morphogenesis, biofilm development and mature biofilms, for the first time suggests anti- C. albicans potential of indole, which may have significant consequences in bacterial-fungal interactions in vivo." @default.
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- W2108185565 date "2012-08-09" @default.
- W2108185565 modified "2023-09-27" @default.
- W2108185565 title "Indole, a bacterial signaling molecule, exhibits inhibitory activity against growth, dimorphism and biofilm formation in Candida albicans" @default.
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- W2108185565 doi "https://doi.org/10.5897/ajmr12.1074" @default.
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