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• W2108185667 abstract "ABSTRACT Mutants with defects in components of the glutathione-glutaredoxin (GSH/Grx) system of Rhodobacter capsulatus were constructed to study its role in defense against oxidative stress and the redox-dependent formation of photosynthetic complexes. The lack of the glutaredoxin 3 gene ( grxC ) or the glutathione synthetase B gene ( gshB ) resulted in lower growth rates under aerobic conditions and higher sensitivity to oxidative stress, confirming the role of the GSH/Grx system in oxidative stress defense. Both mutants are highly sensitive to disulfide stress, indicating a major contribution of the GSH/Grx system to the thiol-disulfide redox buffer in the cytoplasm. Like mutations in the thioredoxin system, mutations in the GSH/Grx system affected the formation of photosynthetic complexes, which is redox dependent in R. capsulatus . Expression of the genes grxC , gshB , grxA for glutaredoxin 1, and gorA for glutathione reductase, all encoding components of the GSH/Grx system, was not induced by oxidative stress. Other genes, for which a role in oxidative stress was established in Escherichia coli , acnA , fpr , fur , and katG , were strongly induced by oxidative stress in R. capsulatus . Mutations in the grxC , and/or gshB , and/or trxC (thioredoxin 2) genes affected expression of these genes, indicating an interplay of the different defense systems against oxidative stress. The OxyR and the SoxRS regulons control the expression of many genes involved in oxidative stress defense in E. coli in response to H 2 O 2 and superoxide, respectively. Our data and the available genome sequence of R. capsulatus suggest that a SoxRS system is lacking but an alternative superoxide specific regulator exists in R. capsulatus. While the expression of gorA and grxA is regulated by H 2 O 2 in E. coli this is not the case in R. capsulatus , indicating that the OxyR regulons of these two species are significantly different." @default.
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• W2108185667 date "2004-10-15" @default.
• W2108185667 modified "2023-10-17" @default.
• W2108185667 title "The Glutathione-Glutaredoxin System in <i>Rhodobacter capsulatus</i> : Part of a Complex Regulatory Network Controlling Defense against Oxidative Stress" @default.
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• W2108185667 doi "https://doi.org/10.1128/jb.186.20.6800-6808.2004" @default.
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