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- W2108201425 endingPage "1" @default.
- W2108201425 startingPage "1" @default.
- W2108201425 abstract "In 1985-1989, erythropoietin (EPO), its receptor (EPOR), and janus kinase 2 were cloned; established to be essential for definitive erythropoiesis; and initially intensely studied. Recently, new impetus, tools, and model systems have emerged to re-examine EPO/EPOR actions, and are addressed in this review. Impetus includes indications that EPO affects significantly more than standard erythroblast survival pathways, the development of novel erythropoiesis-stimulating agents, increasing evidence for EPO/EPOR cytoprotection of ischemically injured tissues, and potential EPO-mediated worsening of tumorigenesis.New findings are reviewed in four functional contexts: (pro)erythroblast survival mechanisms, new candidate EPO/EPOR effects on erythroid cell development and new EPOR responses, EPOR downmodulation and trafficking, and novel erythropoiesis-stimulating agents.As Current Opinion, this monograph seeks to summarize, and provoke, new EPO/EPOR action concepts. Specific problems addressed include: beyond (and before) BCL-XL, what key survival factors are deployed in early-stage proerythroblasts? Are distinct EPO/EPOR signals transduced in stage-selective fashions? Is erythroblast proliferation also modulated by EPO/EPOR signals? What functions are subserved by new noncanonical EPO/EPOR response factors (e.g. podocalyxin like-1, tribbles 3, reactive oxygen species, and nuclear factor kappa B)? What key regulators mediate EPOR inhibition and trafficking? And for emerging erythropoiesis-stimulating agents, to what extent do activities parallel EPOs (or differ in advantageous, potentially complicating ways, or both)?" @default.
- W2108201425 created "2016-06-24" @default.
- W2108201425 creator A5020130202 @default.
- W2108201425 creator A5038598658 @default.
- W2108201425 creator A5059671953 @default.
- W2108201425 date "2010-02-01" @default.
- W2108201425 modified "2023-09-26" @default.
- W2108201425 title "Erythropoietin receptor response circuits" @default.
- W2108201425 cites W111714966 @default.
- W2108201425 cites W1504583940 @default.
- W2108201425 cites W1541049769 @default.
- W2108201425 cites W1554718783 @default.
- W2108201425 cites W1581289874 @default.
- W2108201425 cites W1586272982 @default.
- W2108201425 cites W1591586450 @default.
- W2108201425 cites W1703867835 @default.
- W2108201425 cites W1835174359 @default.
- W2108201425 cites W1964709256 @default.
- W2108201425 cites W1965209932 @default.
- W2108201425 cites W1966010937 @default.
- W2108201425 cites W1966021795 @default.
- W2108201425 cites W1967351404 @default.
- W2108201425 cites W1969376484 @default.
- W2108201425 cites W1972927903 @default.
- W2108201425 cites W1978639463 @default.
- W2108201425 cites W1979130916 @default.
- W2108201425 cites W1983297758 @default.
- W2108201425 cites W1984803306 @default.
- W2108201425 cites W1985562310 @default.
- W2108201425 cites W1988373179 @default.
- W2108201425 cites W1988846200 @default.
- W2108201425 cites W1990306845 @default.
- W2108201425 cites W1993675257 @default.
- W2108201425 cites W1994485879 @default.
- W2108201425 cites W1995521762 @default.
- W2108201425 cites W1995829644 @default.
- W2108201425 cites W1995979833 @default.
- W2108201425 cites W1997672074 @default.
- W2108201425 cites W1998436030 @default.
- W2108201425 cites W2002189627 @default.
- W2108201425 cites W2002782759 @default.
- W2108201425 cites W2005868568 @default.
- W2108201425 cites W2006775922 @default.
- W2108201425 cites W2007809048 @default.
- W2108201425 cites W2009621679 @default.
- W2108201425 cites W2009857536 @default.
- W2108201425 cites W2012421877 @default.
- W2108201425 cites W2013196085 @default.
- W2108201425 cites W2014069517 @default.
- W2108201425 cites W2015357376 @default.
- W2108201425 cites W2017828532 @default.
- W2108201425 cites W2018054628 @default.
- W2108201425 cites W2019289959 @default.
- W2108201425 cites W2020562174 @default.
- W2108201425 cites W2021439199 @default.
- W2108201425 cites W2022499629 @default.
- W2108201425 cites W2023257711 @default.
- W2108201425 cites W2023720146 @default.
- W2108201425 cites W2024591653 @default.
- W2108201425 cites W2025091441 @default.
- W2108201425 cites W2026452824 @default.
- W2108201425 cites W2028506074 @default.
- W2108201425 cites W2028628328 @default.
- W2108201425 cites W2030219313 @default.
- W2108201425 cites W2031407638 @default.
- W2108201425 cites W2033687970 @default.
- W2108201425 cites W2037317430 @default.
- W2108201425 cites W2038082643 @default.
- W2108201425 cites W2038240008 @default.
- W2108201425 cites W2038486294 @default.
- W2108201425 cites W2039137515 @default.
- W2108201425 cites W2040551905 @default.
- W2108201425 cites W2040734118 @default.
- W2108201425 cites W2042216712 @default.
- W2108201425 cites W2042657642 @default.
- W2108201425 cites W2042920536 @default.
- W2108201425 cites W2043058037 @default.
- W2108201425 cites W2044608996 @default.
- W2108201425 cites W2046312189 @default.
- W2108201425 cites W2047129845 @default.
- W2108201425 cites W2049545543 @default.
- W2108201425 cites W2051066066 @default.
- W2108201425 cites W2052553321 @default.
- W2108201425 cites W2055736709 @default.
- W2108201425 cites W2056995253 @default.
- W2108201425 cites W2059175990 @default.
- W2108201425 cites W2059851299 @default.
- W2108201425 cites W2065549220 @default.
- W2108201425 cites W2068691950 @default.
- W2108201425 cites W2069163830 @default.
- W2108201425 cites W2070395474 @default.
- W2108201425 cites W2071203725 @default.
- W2108201425 cites W2071797615 @default.
- W2108201425 cites W2074503465 @default.
- W2108201425 cites W2076190156 @default.
- W2108201425 cites W2077147171 @default.
- W2108201425 cites W2077426010 @default.
- W2108201425 cites W2080846743 @default.