FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108203291> ?p ?o ?g. }

• W2108203291 endingPage "5424" @default.
• W2108203291 startingPage "5412" @default.
• W2108203291 abstract "The human autoantigen La is a 50-kDa protein which binds to the 3' termini of virtually all nascent polymerase III transcripts. Experiments with mammalian transcription extracts have led to the proposal that the La protein is required for multiple rounds of transcription by RNA polymerase III (E. Gottlieb and J. A. Steitz, EMBO J. 8:851-861, 1989; R. J. Maraia, D. J. Kenan, and J. D. Keene, Mol. Cell. Biol. 14:2147-2158, 1994). Although La protein homologs have been identified in a variety of vertebrate species, the protein has not been identified in invertebrates. In order to begin a genetic analysis of La protein function, we have characterized homologs of the La protein in the fruit fly Drosophila melanogaster and the yeast Saccharomyces cerevisiae. We show that both the Drosophila and yeast La proteins are bound to precursors of polymerase III RNAs in vivo. The Drosophila and yeast proteins resemble the human La protein in their biochemical properties, as both proteins can be partially purified from cells by a procedure previously devised to purify the human protein. Similarly to vertebrate La proteins, the Drosophila and yeast homologs preferentially bind RNAs that terminate with a 3' hydroxyl. Despite the fact that the La protein is conserved between humans and Saccharomyces cerevisiae, yeast cells containing a null allele of the gene encoding the La protein are viable, suggesting that another protein(s) plays a functionally redundant role." @default.
• W2108203291 created "2016-06-24" @default.
• W2108203291 creator A5072529770 @default.
• W2108203291 creator A5087696102 @default.
• W2108203291 date "1994-08-01" @default.
• W2108203291 modified "2023-10-13" @default.
• W2108203291 title "La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth." @default.
• W2108203291 cites W115648077 @default.
• W2108203291 cites W1496392745 @default.
• W2108203291 cites W1496430412 @default.
• W2108203291 cites W1510238178 @default.
• W2108203291 cites W1525091092 @default.
• W2108203291 cites W1561796980 @default.
• W2108203291 cites W1565674725 @default.
• W2108203291 cites W1582424095 @default.
• W2108203291 cites W1598208661 @default.
• W2108203291 cites W1603778040 @default.
• W2108203291 cites W1605923556 @default.
• W2108203291 cites W1620364639 @default.
• W2108203291 cites W1622955452 @default.
• W2108203291 cites W1820076796 @default.
• W2108203291 cites W1845284873 @default.
• W2108203291 cites W1871134247 @default.
• W2108203291 cites W1912540205 @default.
• W2108203291 cites W1916946291 @default.
• W2108203291 cites W1976732266 @default.
• W2108203291 cites W1977318874 @default.
• W2108203291 cites W1979531698 @default.
• W2108203291 cites W1982764945 @default.
• W2108203291 cites W1989463841 @default.
• W2108203291 cites W1990944487 @default.
• W2108203291 cites W1994719559 @default.
• W2108203291 cites W1995152619 @default.
• W2108203291 cites W2019562739 @default.
• W2108203291 cites W2026395694 @default.
• W2108203291 cites W2032965219 @default.
• W2108203291 cites W2040232267 @default.
• W2108203291 cites W2048999323 @default.
• W2108203291 cites W2050845473 @default.
• W2108203291 cites W2072927794 @default.
• W2108203291 cites W2077248019 @default.
• W2108203291 cites W2078819000 @default.
• W2108203291 cites W2094778829 @default.
• W2108203291 cites W210302837 @default.
• W2108203291 cites W2104613205 @default.
• W2108203291 cites W2110890019 @default.
• W2108203291 cites W2119722433 @default.
• W2108203291 cites W2120713755 @default.
• W2108203291 cites W2122538520 @default.
• W2108203291 cites W2141216907 @default.
• W2108203291 cites W2165597690 @default.
• W2108203291 cites W2169333620 @default.
• W2108203291 cites W2288436650 @default.
• W2108203291 cites W284187410 @default.
• W2108203291 cites W297331893 @default.
• W2108203291 doi "https://doi.org/10.1128/mcb.14.8.5412" @default.
• W2108203291 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/359060" @default.
• W2108203291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8035818" @default.
• W2108203291 hasPublicationYear "1994" @default.
• W2108203291 type Work @default.
• W2108203291 sameAs 2108203291 @default.
• W2108203291 citedByCount "86" @default.
• W2108203291 countsByYear W21082032912012 @default.
• W2108203291 countsByYear W21082032912013 @default.
• W2108203291 countsByYear W21082032912014 @default.
• W2108203291 countsByYear W21082032912015 @default.
• W2108203291 countsByYear W21082032912016 @default.
• W2108203291 countsByYear W21082032912017 @default.
• W2108203291 countsByYear W21082032912018 @default.
• W2108203291 countsByYear W21082032912019 @default.
• W2108203291 countsByYear W21082032912021 @default.
• W2108203291 crossrefType "journal-article" @default.
• W2108203291 hasAuthorship W2108203291A5072529770 @default.
• W2108203291 hasAuthorship W2108203291A5087696102 @default.
• W2108203291 hasBestOaLocation W21082032911 @default.
• W2108203291 hasConcept C101762097 @default.
• W2108203291 hasConcept C104317684 @default.
• W2108203291 hasConcept C138885662 @default.
• W2108203291 hasConcept C150194340 @default.
• W2108203291 hasConcept C153911025 @default.
• W2108203291 hasConcept C179247698 @default.
• W2108203291 hasConcept C179926584 @default.
• W2108203291 hasConcept C181199279 @default.
• W2108203291 hasConcept C27750908 @default.
• W2108203291 hasConcept C2777576037 @default.
• W2108203291 hasConcept C2779222958 @default.
• W2108203291 hasConcept C2780104201 @default.
• W2108203291 hasConcept C41895202 @default.
• W2108203291 hasConcept C54355233 @default.
• W2108203291 hasConcept C55493867 @default.
• W2108203291 hasConcept C64350747 @default.
• W2108203291 hasConcept C71095615 @default.
• W2108203291 hasConcept C86803240 @default.
• W2108203291 hasConceptScore W2108203291C101762097 @default.
• W2108203291 hasConceptScore W2108203291C104317684 @default.
• W2108203291 hasConceptScore W2108203291C138885662 @default.
• W2108203291 hasConceptScore W2108203291C150194340 @default.
• W2108203291 hasConceptScore W2108203291C153911025 @default.

• next