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• W2108205859 abstract "Apicomplexan protozoan pathogens avoid destruction and establish a replicative niche within host cells by forming a nonfusogenic parasitophorous vacuole (PV). Here we present evidence for lysosome-mediated degradation of Toxoplasma gondii after invasion of macrophages activated in vivo. Pathogen elimination was dependent on the interferon γ inducible-p47 GTPase, IGTP, required PI3K activity, and was preceded by PV membrane indentation, vesiculation, disruption, and, surprisingly, stripping of the parasite plasma membrane. Denuded parasites were enveloped in autophagosome-like vacuoles, which ultimately fused with lysosomes. These observations outline a series of mechanisms used by effector cells to redirect the fate of a classically nonfusogenic intracellular pathogen toward a path of immune elimination." @default.
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• W2108205859 date "2006-08-28" @default.
• W2108205859 modified "2023-10-15" @default.
• W2108205859 title "Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages" @default.
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• W2108205859 doi "https://doi.org/10.1084/jem.20061318" @default.
• W2108205859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2118399" @default.
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