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- W2108214635 abstract "The mechanisms of export of RNA from the nucleus are poorly understood; however, several viral proteins modulate nucleocytoplasmic transport of mRNA. Among these are the adenoviral proteins E1B-55kDa and E4-34kDa. Late in infection, these proteins inhibit export of host transcripts and promote export of viral mRNA. To investigate the mechanism by which these proteins act, we have expressed them in Saccharomyces cerevisiae. Overexpression of either or both proteins has no obvious effect on cell growth. By contrast, overexpression of E1B-55kDa bearing a nuclear localization signal (NLS) dramatically inhibits cell growth. In this situation, the NLS-E1B-55kDa protein is localized to the nuclear periphery, fibrous material is seen in the nucleoplasm, and poly(A)+ RNA accumulates in the nucleus. Simultaneous overexpression of E4-34kDa bearing or lacking an NLS does not modify these effects. We discuss the mechanisms of selective mRNA transport." @default.
- W2108214635 created "2016-06-24" @default.
- W2108214635 creator A5005290527 @default.
- W2108214635 creator A5041291817 @default.
- W2108214635 creator A5061332432 @default.
- W2108214635 date "1995-08-01" @default.
- W2108214635 modified "2023-09-25" @default.
- W2108214635 title "Adenoviral E1B-55kDa protein inhibits yeast mRNA export and perturbs nuclear structure." @default.
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- W2108214635 doi "https://doi.org/10.1073/pnas.92.16.7372" @default.
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