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- W2108221620 endingPage "683" @default.
- W2108221620 startingPage "652" @default.
- W2108221620 abstract "The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. Consistent with its central role in this process, much prior work has illustrated that Mcm2-7 loading and activation are landmark events in the regulation of DNA replication. Unlike any other hexameric helicase, Mcm2-7 is composed of six unique and essential subunits. Although the unusual oligomeric nature of this complex has long hampered biochemical investigations, recent advances with both the eukaryotic as well as the simpler archaeal Mcm complexes provide mechanistic insight into their function. In contrast to better-studied homohexameric helicases, evidence suggests that the six Mcm2-7 complex ATPase active sites are functionally distinct and are likely specialized to accommodate the regulatory constraints of the eukaryotic process." @default.
- W2108221620 created "2016-06-24" @default.
- W2108221620 creator A5048445038 @default.
- W2108221620 creator A5061031479 @default.
- W2108221620 date "2009-12-01" @default.
- W2108221620 modified "2023-10-16" @default.
- W2108221620 title "The Mcm Complex: Unwinding the Mechanism of a Replicative Helicase" @default.
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