Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108240317> ?p ?o ?g. }
- W2108240317 endingPage "136" @default.
- W2108240317 startingPage "115" @default.
- W2108240317 abstract "Much recent progress has been made in the identification of new tumor antigens and their epitopes that may serve as potential cancer vaccines. Many of these have been studied as synthetic peptide vaccines corresponding to epitopes identified as presented by particular common human class I HLA molecules, especially HLAA2.1, the most common human class I molecule. Although a number of strategies for immunization against cancer have been investigated, no strategy targeting a specific antigen has yet proven consistently more clinically effective than synthetic peptides. Peptides have the advantage that they can be easily modified by epitope enhancement to improve binding to the MHC molecule or the T cell receptor, and they can be combined with cytokines, chemokines, and costimulatory molecules to increase vaccine potency and steer the responses toward a desired phenotype, such as CTL or Th1 cells. Peptides can also be coated onto dendritic cells, the ultimate professional antigen presenting cell, to bypass any defect in antigen-presenting cell function or maturation related to the presence of the cancer. Thus, as both research tools and as potential clinical vaccines, synthetic peptides remain at the forefront of research in the vaccine immunotherapy of cancer." @default.
- W2108240317 created "2016-06-24" @default.
- W2108240317 creator A5001322101 @default.
- W2108240317 creator A5056265030 @default.
- W2108240317 creator A5062001972 @default.
- W2108240317 date "2005-01-01" @default.
- W2108240317 modified "2023-10-11" @default.
- W2108240317 title "Peptide Vaccines Against Cancer" @default.
- W2108240317 cites W1445322489 @default.
- W2108240317 cites W1482760750 @default.
- W2108240317 cites W1488522044 @default.
- W2108240317 cites W1501518736 @default.
- W2108240317 cites W1501664116 @default.
- W2108240317 cites W1509190187 @default.
- W2108240317 cites W1519513582 @default.
- W2108240317 cites W1522781268 @default.
- W2108240317 cites W1538328956 @default.
- W2108240317 cites W1554669092 @default.
- W2108240317 cites W1559556959 @default.
- W2108240317 cites W1574892766 @default.
- W2108240317 cites W1589097025 @default.
- W2108240317 cites W1592881318 @default.
- W2108240317 cites W1603697150 @default.
- W2108240317 cites W1643293176 @default.
- W2108240317 cites W1660413876 @default.
- W2108240317 cites W1661544713 @default.
- W2108240317 cites W1669165205 @default.
- W2108240317 cites W1678167583 @default.
- W2108240317 cites W1790202563 @default.
- W2108240317 cites W1823669223 @default.
- W2108240317 cites W1831319429 @default.
- W2108240317 cites W1893184572 @default.
- W2108240317 cites W1924533991 @default.
- W2108240317 cites W1928212615 @default.
- W2108240317 cites W1936376546 @default.
- W2108240317 cites W1963914430 @default.
- W2108240317 cites W1965170608 @default.
- W2108240317 cites W1967577151 @default.
- W2108240317 cites W1969057879 @default.
- W2108240317 cites W1969372348 @default.
- W2108240317 cites W1971985122 @default.
- W2108240317 cites W1972423862 @default.
- W2108240317 cites W1977234022 @default.
- W2108240317 cites W1978094859 @default.
- W2108240317 cites W1978146796 @default.
- W2108240317 cites W1980958970 @default.
- W2108240317 cites W1982451462 @default.
- W2108240317 cites W1983739608 @default.
- W2108240317 cites W1983806918 @default.
- W2108240317 cites W1983954483 @default.
- W2108240317 cites W1987350137 @default.
- W2108240317 cites W1990198913 @default.
- W2108240317 cites W1990359665 @default.
- W2108240317 cites W1991330340 @default.
- W2108240317 cites W1992909383 @default.
- W2108240317 cites W1994194611 @default.
- W2108240317 cites W2001824569 @default.
- W2108240317 cites W2001962665 @default.
- W2108240317 cites W2003546467 @default.
- W2108240317 cites W2004962555 @default.
- W2108240317 cites W2005190251 @default.
- W2108240317 cites W2006038974 @default.
- W2108240317 cites W2006653124 @default.
- W2108240317 cites W2006987944 @default.
- W2108240317 cites W2008564146 @default.
- W2108240317 cites W2010340952 @default.
- W2108240317 cites W2012148175 @default.
- W2108240317 cites W2014733698 @default.
- W2108240317 cites W2015620306 @default.
- W2108240317 cites W2016629087 @default.
- W2108240317 cites W2017873985 @default.
- W2108240317 cites W2023985105 @default.
- W2108240317 cites W2026763255 @default.
- W2108240317 cites W2030334592 @default.
- W2108240317 cites W2031908218 @default.
- W2108240317 cites W2034845495 @default.
- W2108240317 cites W2036272741 @default.
- W2108240317 cites W2036961863 @default.
- W2108240317 cites W2038500217 @default.
- W2108240317 cites W2039356532 @default.
- W2108240317 cites W2041110737 @default.
- W2108240317 cites W2041440798 @default.
- W2108240317 cites W2041601304 @default.
- W2108240317 cites W2041679777 @default.
- W2108240317 cites W2042713052 @default.
- W2108240317 cites W2043052307 @default.
- W2108240317 cites W2045799644 @default.
- W2108240317 cites W2046094097 @default.
- W2108240317 cites W2048073154 @default.
- W2108240317 cites W2049364599 @default.
- W2108240317 cites W2049648035 @default.
- W2108240317 cites W2049997077 @default.
- W2108240317 cites W2053976077 @default.
- W2108240317 cites W2054129665 @default.
- W2108240317 cites W2054275272 @default.
- W2108240317 cites W2054458001 @default.
- W2108240317 cites W2055985033 @default.
- W2108240317 cites W2056102876 @default.