FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108251718> ?p ?o ?g. }

• W2108251718 endingPage "L200" @default.
• W2108251718 startingPage "L191" @default.
• W2108251718 abstract "Undersulfation of the basement membrane matrix of alveolar type II (AT2) cells compared with that of neighboring type I cells is believed to account for some of the known morphological and functional differences between these pneumocytes. Heparin, a model for sulfated components of basement membrane matrices, is known to inhibit fibroblast growth factor (FGF)-2-stimulated DNA synthesis as well as gene expression of FGF-2 and its receptor in AT2 cells. To determine whether these end points result from specific effects of heparin on FGF-related signaling pathways, isolated rat AT2 cells were treated with 100 ng/ml FGF-1 or FGF-2 in the presence of up to 500 microg/ml heparin. In addition, experiments were done on cells grown in the presence of 20 mM sodium chlorate (sulfation inhibitor). High-dose heparin reduced FGF-1- or FGF-2-stimulated phosphorylation of mitogen-activated protein kinase kinases (MEK1/2), p44/42 mitogen-activated protein kinases (MAPK/ERK1/2), stress-activated protein kinase/c-Jun NH(2)-terminal kinase, Akt/protein kinase B, and p90(RSK). FGF-2-stimulated signaling was more sensitive to heparin's effects than was signaling stimulated by FGF-1. Heparin had an additive effect on the reduced [(3)H]thymidine incorporation in FGF-2-treated AT2 cells caused by inhibition of the MEK/ERK pathway by the MEK inhibitor PD-98059. The data suggest that heparin's known capacity to alter DNA synthesis and, possibly, other biological end points is realized via cross talk between multiple signaling pathways." @default.
• W2108251718 created "2016-06-24" @default.
• W2108251718 creator A5017538833 @default.
• W2108251718 creator A5037287526 @default.
• W2108251718 creator A5045618487 @default.
• W2108251718 creator A5082197548 @default.
• W2108251718 creator A5083893114 @default.
• W2108251718 date "2004-07-01" @default.
• W2108251718 modified "2023-10-15" @default.
• W2108251718 title "Heparin affects signaling pathways stimulated by fibroblast growth factor-1 and -2 in type II cells" @default.
• W2108251718 cites W107992251 @default.
• W2108251718 cites W1854803455 @default.
• W2108251718 cites W1944551911 @default.
• W2108251718 cites W1964840302 @default.
• W2108251718 cites W1966125684 @default.
• W2108251718 cites W1966204112 @default.
• W2108251718 cites W1978596841 @default.
• W2108251718 cites W1984251429 @default.
• W2108251718 cites W1997946222 @default.
• W2108251718 cites W2008403225 @default.
• W2108251718 cites W2009830583 @default.
• W2108251718 cites W2020726154 @default.
• W2108251718 cites W2023552163 @default.
• W2108251718 cites W2042176329 @default.
• W2108251718 cites W2055494379 @default.
• W2108251718 cites W2059804455 @default.
• W2108251718 cites W2061716134 @default.
• W2108251718 cites W2063100490 @default.
• W2108251718 cites W2070584222 @default.
• W2108251718 cites W2072190846 @default.
• W2108251718 cites W2072303535 @default.
• W2108251718 cites W2073982646 @default.
• W2108251718 cites W2094418078 @default.
• W2108251718 cites W2114650637 @default.
• W2108251718 cites W2141376240 @default.
• W2108251718 cites W2156172361 @default.
• W2108251718 cites W2156876763 @default.
• W2108251718 cites W2162093697 @default.
• W2108251718 cites W2163170931 @default.
• W2108251718 cites W2165893661 @default.
• W2108251718 cites W2257333659 @default.
• W2108251718 cites W2279411086 @default.
• W2108251718 cites W2291002272 @default.
• W2108251718 cites W2402077000 @default.
• W2108251718 cites W2443080206 @default.
• W2108251718 cites W4255042798 @default.
• W2108251718 doi "https://doi.org/10.1152/ajplung.00284.2003" @default.
• W2108251718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14966081" @default.
• W2108251718 hasPublicationYear "2004" @default.
• W2108251718 type Work @default.
• W2108251718 sameAs 2108251718 @default.
• W2108251718 citedByCount "37" @default.
• W2108251718 countsByYear W21082517182012 @default.
• W2108251718 countsByYear W21082517182014 @default.
• W2108251718 countsByYear W21082517182015 @default.
• W2108251718 countsByYear W21082517182016 @default.
• W2108251718 countsByYear W21082517182017 @default.
• W2108251718 countsByYear W21082517182018 @default.
• W2108251718 countsByYear W21082517182021 @default.
• W2108251718 countsByYear W21082517182022 @default.
• W2108251718 countsByYear W21082517182023 @default.
• W2108251718 crossrefType "journal-article" @default.
• W2108251718 hasAuthorship W2108251718A5017538833 @default.
• W2108251718 hasAuthorship W2108251718A5037287526 @default.
• W2108251718 hasAuthorship W2108251718A5045618487 @default.
• W2108251718 hasAuthorship W2108251718A5082197548 @default.
• W2108251718 hasAuthorship W2108251718A5083893114 @default.
• W2108251718 hasConcept C132149769 @default.
• W2108251718 hasConcept C153911025 @default.
• W2108251718 hasConcept C170493617 @default.
• W2108251718 hasConcept C184235292 @default.
• W2108251718 hasConcept C185592680 @default.
• W2108251718 hasConcept C195794163 @default.
• W2108251718 hasConcept C2777557582 @default.
• W2108251718 hasConcept C55493867 @default.
• W2108251718 hasConcept C57074206 @default.
• W2108251718 hasConcept C62478195 @default.
• W2108251718 hasConcept C74373430 @default.
• W2108251718 hasConcept C75217442 @default.
• W2108251718 hasConcept C86803240 @default.
• W2108251718 hasConcept C95444343 @default.
• W2108251718 hasConcept C97029542 @default.
• W2108251718 hasConceptScore W2108251718C132149769 @default.
• W2108251718 hasConceptScore W2108251718C153911025 @default.
• W2108251718 hasConceptScore W2108251718C170493617 @default.
• W2108251718 hasConceptScore W2108251718C184235292 @default.
• W2108251718 hasConceptScore W2108251718C185592680 @default.
• W2108251718 hasConceptScore W2108251718C195794163 @default.
• W2108251718 hasConceptScore W2108251718C2777557582 @default.
• W2108251718 hasConceptScore W2108251718C55493867 @default.
• W2108251718 hasConceptScore W2108251718C57074206 @default.
• W2108251718 hasConceptScore W2108251718C62478195 @default.
• W2108251718 hasConceptScore W2108251718C74373430 @default.
• W2108251718 hasConceptScore W2108251718C75217442 @default.
• W2108251718 hasConceptScore W2108251718C86803240 @default.
• W2108251718 hasConceptScore W2108251718C95444343 @default.
• W2108251718 hasConceptScore W2108251718C97029542 @default.
• W2108251718 hasIssue "1" @default.

• next