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• W2108254616 endingPage "1633" @default.
• W2108254616 startingPage "1623" @default.
• W2108254616 abstract "Kinetics of mature T cell generation in the thymus of normal or major histocompatibility complex (MHC) class I- or II-deficient mice were studied by the bromodeoxyuridine pulse labeling method. As previously described, the early activation and final maturation phases were found to be synchronous for the two T cell lineages, but CD4+8- cells were generated faster than CD4-8+ cells in MHC class I- and II-deficient mice, respectively. CD8 downregulation started on day 2 after cell proliferation even in the absence of MHC class II expression. CD8 downregulation thus appears to be stochastic at its beginning. By contrast, CD4 shut-off was found totally instructive, as the generation of CD4lo8+ cells with a high TCR density was not observed in class I-deficient mice. The analysis of the V beta 14 TCR frequencies in CD4/8 subsets in normal and MHC-deficient mice confirmed that CD4 and CD8 generation pathways are not symmetrical. These findings show that commitment towards the CD4+8- or CD4-8+ phenotype is controlled at the CD8lo step for the former and at the CD4+8+ double-positive stage for the latter." @default.
• W2108254616 created "2016-06-24" @default.
• W2108254616 creator A5055186439 @default.
• W2108254616 creator A5058410938 @default.
• W2108254616 creator A5068468019 @default.
• W2108254616 date "1995-05-01" @default.
• W2108254616 modified "2023-09-24" @default.
• W2108254616 title "Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway." @default.
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• W2108254616 doi "https://doi.org/10.1084/jem.181.5.1623" @default.
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• W2108254616 hasPublicationYear "1995" @default.
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