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• W2108264967 abstract "The brain substrates involved in the effect of cocaine on brain stimulation reward, in the psychomotor activation associated with cocaine, and in cocaine self-administration appear to be focused on the medial forebrain bundle and its connections with the basal forebrain, notably the nucleus accumbens. Chronic access to cocaine produces a withdrawal state as reflected in increases in brain stimulation reward thresholds, and this change in reward threshold appears to be opposite to the actions of the drug administered acutely. These effects are thought to reflect a change in the activity of reward elements in the medial forebrain bundle and may be responsible for the negative reinforcing state associated with the anhedonia of cocaine withdrawal. Opiate receptors particularly sensitive to the reinforcing effects of heroin also appear to be located in the region of the nucleus accumbens and the ventral tegmental area. There is good evidence for both dopamine-dependent and dopamine-independent opioid interactions in the ventral tegmental-nucleus accumbens connection. In addition, the opiate receptors in the region of the nucleus accumbens may become sensitized during the course of opiate withdrawal and thus become responsible for the aversive stimulus effects of opiate dependence. Reliable measures of the acute reinforcing effects of ethanol have been established in rat models, and substantial evidence exists to show that non-deprived rats will orally self-administer pharmacologically relevant amounts of ethanol in lever-press choice situations. Neuropharmacological studies of ethanol reinforcement in non-dependent rats suggest important roles for serotonin, GABA and dopamine. A role for opioid peptides in ethanol reinforcement may reflect more general actions of opioid peptides in consummatory behavior. Studies of ethanol dependence have implicated brain GABAergic and CRF systems in the more motivational aspects of withdrawal. Future studies will need to focus on the common neurobiologic changes associated with all these drugs, particularly regarding their hedonic and motivational properties." @default.
• W2108264967 created "2016-06-24" @default.
• W2108264967 creator A5075246876 @default.
• W2108264967 date "1992-06-01" @default.
• W2108264967 modified "2023-10-16" @default.
• W2108264967 title "Neural Mechanisms of Drug Reinforcement" @default.
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• W2108264967 cites W1967875997 @default.
• W2108264967 cites W1970079539 @default.
• W2108264967 cites W1970541082 @default.
• W2108264967 cites W1971518639 @default.
• W2108264967 cites W1974692779 @default.
• W2108264967 cites W1975264659 @default.
• W2108264967 cites W1977008035 @default.
• W2108264967 cites W1978509199 @default.
• W2108264967 cites W1982720467 @default.
• W2108264967 cites W1982875691 @default.
• W2108264967 cites W1987336534 @default.
• W2108264967 cites W1993202660 @default.
• W2108264967 cites W1994611964 @default.
• W2108264967 cites W1996364906 @default.
• W2108264967 cites W1998096274 @default.
• W2108264967 cites W1998134028 @default.
• W2108264967 cites W1999063330 @default.
• W2108264967 cites W2002063450 @default.
• W2108264967 cites W2003409321 @default.
• W2108264967 cites W2005239439 @default.
• W2108264967 cites W2005897842 @default.
• W2108264967 cites W2005997674 @default.
• W2108264967 cites W2010439035 @default.
• W2108264967 cites W2010569958 @default.
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• W2108264967 cites W2020860451 @default.
• W2108264967 cites W2021526152 @default.
• W2108264967 cites W2021923825 @default.
• W2108264967 cites W2024245549 @default.
• W2108264967 cites W2025495736 @default.
• W2108264967 cites W2025569055 @default.
• W2108264967 cites W2025884351 @default.
• W2108264967 cites W2026970523 @default.
• W2108264967 cites W2028650350 @default.
• W2108264967 cites W2029769300 @default.
• W2108264967 cites W2031232417 @default.
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• W2108264967 cites W2035974852 @default.
• W2108264967 cites W2036136942 @default.
• W2108264967 cites W2040534985 @default.
• W2108264967 cites W2045284958 @default.
• W2108264967 cites W2046319204 @default.
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• W2108264967 doi "https://doi.org/10.1111/j.1749-6632.1992.tb25966.x" @default.
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