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• W2108265384 abstract "ABSTRACT We performed a mutational analysis of the NS3 helicase of dengue virus to test insights gleaned from its crystal structure and identified four residues in the full-length protein that severely impaired either its RTPase and ATPase (Arg-457-458, Arg-460, Arg-463) or helicase (Ile-365, Arg-376) activity. Alanine substitution of Lys-396, which is located at the surface of domain II, drastically reduced all three enzymatic activities. Our study points to a pocket at the surface of domain II that may be suitable for the design of allosteric inhibitors." @default.
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• W2108265384 date "2006-07-01" @default.
• W2108265384 modified "2023-10-16" @default.
• W2108265384 title "Structure-Based Mutational Analysis of the NS3 Helicase from Dengue Virus" @default.
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• W2108265384 doi "https://doi.org/10.1128/jvi.02215-05" @default.
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