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• W2108267037 abstract "The role of mass drug administration (MDA) and the implementation of transmission reduction measures are essential to successfully control and eliminate a wide range of NTDs, including the ocular disease trachoma. Immunity to trachoma infection acts by reducing the duration of an individual's infectious period and by reducing their infectivity with each successive infection.In this study, we use a model of trachoma infection, which includes population immunity, to explore the impact of treatment and transmission reduction measures on trachoma prevalence. Specifically, we investigate the possibility of increasing transmissibility of trachoma arising as MDA and transmission reduction measures are scaled up in endemic settings.We demonstrate this increase in transmissibility by calculating the effective reproduction number during several simulated control programmes and show that it is related to a decrease in the level of immunity in the population.This effect should be studied in the field by measuring the rate of return of infection and disease in at least two separate age groups. If the decline of population immunity is operating, it should be accounted for when planning for the GET2020 goal of eliminating blinding trachoma by 2020." @default.
• W2108267037 created "2016-06-24" @default.
• W2108267037 creator A5002322327 @default.
• W2108267037 creator A5081243378 @default.
• W2108267037 date "2015-10-22" @default.
• W2108267037 modified "2023-10-17" @default.
• W2108267037 title "Possible changes in the transmissibility of trachoma following MDA and transmission reduction: implications for the GET2020 goals" @default.
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• W2108267037 doi "https://doi.org/10.1186/s13071-015-1133-6" @default.
• W2108267037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4618927" @default.
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• W2108267037 hasPublicationYear "2015" @default.
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