Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108272915> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2108272915 endingPage "646" @default.
- W2108272915 startingPage "643" @default.
- W2108272915 abstract "This study assessed the pharmacodynamic activity of ertapenem against multidrug-resistant (MDR) genotypically characterized extended-spectrum β-lactamase (ESBL)-producing Escherichia coli using an in vitro model. Six ESBL-producing E. coli with the CTX-M-15 genotype were studied. All six strains were MDR (defined as resistance to third-generation cephalosporins and ≥two other unrelated antimicrobial classes). The in vitro pharmacodynamic model was inoculated with 1 × 106 cfu/mL, and ertapenem was dosed once daily at 0 and 24 h to simulate free (f) Cmax and t1/2 obtained after a standard 1 g intravenous once-daily dose in healthy volunteers (fCmax, 15 mg/L; t1/2, 4 h). Sampling was performed over 48 h to assess viable growth and resistance selection. Ertapenem T>MIC ≥98% (ertapenem MICs ≤0.25 mg/L) resulted in bactericidal (≥3 log10 killing) activity at 6, 12, 24 and 48 h against all strains. Eradication of organisms from the in vitro model (below the level of detection) occurred at 2 h followed by slow regrowth of the majority of the strains (5 of 6) over 12, 24 and 48 h time points. Despite limited regrowth, ertapenem achieved a bactericidal effect against all strains (all time points) over the 48 h study period. Ertapenem was rapidly bactericidal (in ∼2 h) against MDR ESBL (CTX-M-15)-producing E. coli (ertapenem MICs ≤0.25 mg/L) when simulating free drug after 1 g intravenous once-daily dosing. This bactericidal activity was maintained over the 48 h experimental period with only minor regrowth, which was not associated with MIC increase from baseline." @default.
- W2108272915 created "2016-06-24" @default.
- W2108272915 creator A5013240642 @default.
- W2108272915 creator A5013550916 @default.
- W2108272915 creator A5033454548 @default.
- W2108272915 creator A5038087307 @default.
- W2108272915 creator A5042772929 @default.
- W2108272915 creator A5090227234 @default.
- W2108272915 date "2008-02-04" @default.
- W2108272915 modified "2023-10-16" @default.
- W2108272915 title "Pharmacodynamic activity of ertapenem versus multidrug-resistant genotypically characterized extended-spectrum -lactamase-producing Escherichia coli using an in vitro model" @default.
- W2108272915 cites W1970243973 @default.
- W2108272915 cites W1974635927 @default.
- W2108272915 cites W1984501836 @default.
- W2108272915 cites W2074016677 @default.
- W2108272915 cites W2110227342 @default.
- W2108272915 cites W2124856650 @default.
- W2108272915 cites W2129620727 @default.
- W2108272915 cites W2138691247 @default.
- W2108272915 cites W2151275236 @default.
- W2108272915 cites W2156446002 @default.
- W2108272915 cites W2162067003 @default.
- W2108272915 doi "https://doi.org/10.1093/jac/dkm533" @default.
- W2108272915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18238885" @default.
- W2108272915 hasPublicationYear "2008" @default.
- W2108272915 type Work @default.
- W2108272915 sameAs 2108272915 @default.
- W2108272915 citedByCount "5" @default.
- W2108272915 countsByYear W21082729152014 @default.
- W2108272915 crossrefType "journal-article" @default.
- W2108272915 hasAuthorship W2108272915A5013240642 @default.
- W2108272915 hasAuthorship W2108272915A5013550916 @default.
- W2108272915 hasAuthorship W2108272915A5033454548 @default.
- W2108272915 hasAuthorship W2108272915A5038087307 @default.
- W2108272915 hasAuthorship W2108272915A5042772929 @default.
- W2108272915 hasAuthorship W2108272915A5090227234 @default.
- W2108272915 hasBestOaLocation W21082729151 @default.
- W2108272915 hasConcept C104317684 @default.
- W2108272915 hasConcept C111113717 @default.
- W2108272915 hasConcept C112705442 @default.
- W2108272915 hasConcept C133936738 @default.
- W2108272915 hasConcept C2778368673 @default.
- W2108272915 hasConcept C2779375183 @default.
- W2108272915 hasConcept C3019249092 @default.
- W2108272915 hasConcept C4937899 @default.
- W2108272915 hasConcept C501593827 @default.
- W2108272915 hasConcept C547475151 @default.
- W2108272915 hasConcept C55493867 @default.
- W2108272915 hasConcept C64778159 @default.
- W2108272915 hasConcept C86803240 @default.
- W2108272915 hasConcept C89423630 @default.
- W2108272915 hasConcept C94665300 @default.
- W2108272915 hasConcept C98274493 @default.
- W2108272915 hasConceptScore W2108272915C104317684 @default.
- W2108272915 hasConceptScore W2108272915C111113717 @default.
- W2108272915 hasConceptScore W2108272915C112705442 @default.
- W2108272915 hasConceptScore W2108272915C133936738 @default.
- W2108272915 hasConceptScore W2108272915C2778368673 @default.
- W2108272915 hasConceptScore W2108272915C2779375183 @default.
- W2108272915 hasConceptScore W2108272915C3019249092 @default.
- W2108272915 hasConceptScore W2108272915C4937899 @default.
- W2108272915 hasConceptScore W2108272915C501593827 @default.
- W2108272915 hasConceptScore W2108272915C547475151 @default.
- W2108272915 hasConceptScore W2108272915C55493867 @default.
- W2108272915 hasConceptScore W2108272915C64778159 @default.
- W2108272915 hasConceptScore W2108272915C86803240 @default.
- W2108272915 hasConceptScore W2108272915C89423630 @default.
- W2108272915 hasConceptScore W2108272915C94665300 @default.
- W2108272915 hasConceptScore W2108272915C98274493 @default.
- W2108272915 hasIssue "3" @default.
- W2108272915 hasLocation W21082729151 @default.
- W2108272915 hasLocation W21082729152 @default.
- W2108272915 hasOpenAccess W2108272915 @default.
- W2108272915 hasPrimaryLocation W21082729151 @default.
- W2108272915 hasRelatedWork W131934017 @default.
- W2108272915 hasRelatedWork W1547716619 @default.
- W2108272915 hasRelatedWork W1566433907 @default.
- W2108272915 hasRelatedWork W1980009488 @default.
- W2108272915 hasRelatedWork W1997106149 @default.
- W2108272915 hasRelatedWork W2006661458 @default.
- W2108272915 hasRelatedWork W2117702513 @default.
- W2108272915 hasRelatedWork W2138399728 @default.
- W2108272915 hasRelatedWork W2910476975 @default.
- W2108272915 hasRelatedWork W4229833473 @default.
- W2108272915 hasVolume "61" @default.
- W2108272915 isParatext "false" @default.
- W2108272915 isRetracted "false" @default.
- W2108272915 magId "2108272915" @default.
- W2108272915 workType "article" @default.