Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108273403> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2108273403 endingPage "235" @default.
- W2108273403 startingPage "226" @default.
- W2108273403 abstract "We have previously demonstrated that carnitine deficiency aggravated paracetamol-induced hepatopathy and carboplatin-induced nephropathy. As a continuum, we have addressed in the current study as to whether carboplatin-induced myelosuppression would be exacerbated by carnitine deficiency. Challenging male Wistar rats with a single dose of carboplatin (35 mg/kg, IP) induced bone marrow suppression manifested as anemia, leucopenia, thrombocytopenia as well as increased frequencies of the micronucleated bone marrow cells; MPCE and MNCE with notable reduction in the P/N ratio. The platinum drug also elevated serum TNF-a and reduced serum free and total carnitine levels. Besides, ATP levels in red and T cells were lowered. Likewise, the mitochondrial membrane potential in T lymphocytes was reduced following the use of the potentiometric dye; JC-1, and this was well correlated with cellular ATP production. Carnitine deficiency exacerbated carboplatin myelotoxicity as it exaggerated all biochemical, hematological and cytogenetic parameters. To address as to whether carnitine deficiency was a causative clue or merely a sequel of carboplatin myelotoxicity, L-carnitine was supplemented ahead of carboplatin challenege. Herein, L-carnitine mitigated all the biochemical, hematological and cytogenetic effects possibly via modulating the release of TNF-a, cellular ATP production and restoring the mitochondrial membrane potential. Irrespective of the mechanisms involved, the current results may afford the potential role for carnitine supplementation as add-on nutraceutical in carboplatin-based chemotherapy." @default.
- W2108273403 created "2016-06-24" @default.
- W2108273403 creator A5003713153 @default.
- W2108273403 creator A5038049484 @default.
- W2108273403 creator A5061908528 @default.
- W2108273403 creator A5073731396 @default.
- W2108273403 date "2014-12-04" @default.
- W2108273403 modified "2023-10-18" @default.
- W2108273403 title "Carnitine Deficiency: A Causative Clue or a Sequel in Carboplatin Myelosuppression" @default.
- W2108273403 cites W1814149396 @default.
- W2108273403 cites W1827991484 @default.
- W2108273403 cites W1935796521 @default.
- W2108273403 cites W195722999 @default.
- W2108273403 cites W1964091382 @default.
- W2108273403 cites W1968818148 @default.
- W2108273403 cites W1973879983 @default.
- W2108273403 cites W1976824591 @default.
- W2108273403 cites W2006349552 @default.
- W2108273403 cites W2011583249 @default.
- W2108273403 cites W2013011950 @default.
- W2108273403 cites W2020316909 @default.
- W2108273403 cites W2022957206 @default.
- W2108273403 cites W2025580987 @default.
- W2108273403 cites W2027253465 @default.
- W2108273403 cites W2027968744 @default.
- W2108273403 cites W2035002706 @default.
- W2108273403 cites W2036062808 @default.
- W2108273403 cites W2037289232 @default.
- W2108273403 cites W2050279564 @default.
- W2108273403 cites W2062690013 @default.
- W2108273403 cites W2062985502 @default.
- W2108273403 cites W2082366830 @default.
- W2108273403 cites W2086669487 @default.
- W2108273403 cites W2094332559 @default.
- W2108273403 cites W2110994703 @default.
- W2108273403 cites W2122172966 @default.
- W2108273403 cites W2158279701 @default.
- W2108273403 cites W2168631974 @default.
- W2108273403 cites W2170833511 @default.
- W2108273403 cites W2183485722 @default.
- W2108273403 cites W2242657415 @default.
- W2108273403 cites W2315801618 @default.
- W2108273403 cites W2401085667 @default.
- W2108273403 cites W2408823874 @default.
- W2108273403 doi "https://doi.org/10.6000/1929-2279.2014.03.04.7" @default.
- W2108273403 hasPublicationYear "2014" @default.
- W2108273403 type Work @default.
- W2108273403 sameAs 2108273403 @default.
- W2108273403 citedByCount "1" @default.
- W2108273403 countsByYear W21082734032016 @default.
- W2108273403 crossrefType "journal-article" @default.
- W2108273403 hasAuthorship W2108273403A5003713153 @default.
- W2108273403 hasAuthorship W2108273403A5038049484 @default.
- W2108273403 hasAuthorship W2108273403A5061908528 @default.
- W2108273403 hasAuthorship W2108273403A5073731396 @default.
- W2108273403 hasConcept C126322002 @default.
- W2108273403 hasConcept C134018914 @default.
- W2108273403 hasConcept C185592680 @default.
- W2108273403 hasConcept C203014093 @default.
- W2108273403 hasConcept C2776694085 @default.
- W2108273403 hasConcept C2778239845 @default.
- W2108273403 hasConcept C2778435403 @default.
- W2108273403 hasConcept C2780007613 @default.
- W2108273403 hasConcept C2781451048 @default.
- W2108273403 hasConcept C71924100 @default.
- W2108273403 hasConcept C98274493 @default.
- W2108273403 hasConceptScore W2108273403C126322002 @default.
- W2108273403 hasConceptScore W2108273403C134018914 @default.
- W2108273403 hasConceptScore W2108273403C185592680 @default.
- W2108273403 hasConceptScore W2108273403C203014093 @default.
- W2108273403 hasConceptScore W2108273403C2776694085 @default.
- W2108273403 hasConceptScore W2108273403C2778239845 @default.
- W2108273403 hasConceptScore W2108273403C2778435403 @default.
- W2108273403 hasConceptScore W2108273403C2780007613 @default.
- W2108273403 hasConceptScore W2108273403C2781451048 @default.
- W2108273403 hasConceptScore W2108273403C71924100 @default.
- W2108273403 hasConceptScore W2108273403C98274493 @default.
- W2108273403 hasIssue "4" @default.
- W2108273403 hasLocation W21082734031 @default.
- W2108273403 hasOpenAccess W2108273403 @default.
- W2108273403 hasPrimaryLocation W21082734031 @default.
- W2108273403 hasRelatedWork W1975536848 @default.
- W2108273403 hasRelatedWork W1992832034 @default.
- W2108273403 hasRelatedWork W2023659097 @default.
- W2108273403 hasRelatedWork W2060523002 @default.
- W2108273403 hasRelatedWork W2070787133 @default.
- W2108273403 hasRelatedWork W2075726447 @default.
- W2108273403 hasRelatedWork W2146211406 @default.
- W2108273403 hasRelatedWork W2163591087 @default.
- W2108273403 hasRelatedWork W2748952813 @default.
- W2108273403 hasRelatedWork W76394038 @default.
- W2108273403 hasVolume "3" @default.
- W2108273403 isParatext "false" @default.
- W2108273403 isRetracted "false" @default.
- W2108273403 magId "2108273403" @default.
- W2108273403 workType "article" @default.