Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108276372> ?p ?o ?g. }
- W2108276372 endingPage "3213" @default.
- W2108276372 startingPage "3203" @default.
- W2108276372 abstract "The use of surface-based methods for the delivery of therapeutics has recently generated increasing interest. These platforms have tremendous potential to minimize detrimental side effects associated with systemic delivery by localizing the therapeutic vehicle, and thus provide higher local doses for improved efficacy. Cationic lipids are one of the most commonly used synthetic carriers for the delivery of genetic cargo, such as DNA and RNA. However, reports on the use of lipid-based films for gene delivery are scarce. Here we investigate the use of a lipid-based film for the in vitro delivery of plasmid DNA. Solid DNA-lipid films show very low levels of transfection, while identical complexes prepared for bolus delivery provide high levels of transfection when used directly. We investigate the mechanism, whereby the activity of these solid-state films is lost and suggest methods for circumventing these challenges and restoring the efficacy of these films as gene delivery platforms. © 2013 American Institute of Chemical Engineers AIChE J, 59: 3203–3213, 2013" @default.
- W2108276372 created "2016-06-24" @default.
- W2108276372 creator A5006465118 @default.
- W2108276372 creator A5008240408 @default.
- W2108276372 creator A5013729741 @default.
- W2108276372 creator A5014800269 @default.
- W2108276372 creator A5021174458 @default.
- W2108276372 creator A5035782538 @default.
- W2108276372 creator A5046886290 @default.
- W2108276372 creator A5054354546 @default.
- W2108276372 date "2013-08-09" @default.
- W2108276372 modified "2023-10-06" @default.
- W2108276372 title "Challenges in nucleic acid-lipid films for transfection" @default.
- W2108276372 cites W1482943240 @default.
- W2108276372 cites W1506102129 @default.
- W2108276372 cites W1520821663 @default.
- W2108276372 cites W1963706636 @default.
- W2108276372 cites W1965364831 @default.
- W2108276372 cites W1965566957 @default.
- W2108276372 cites W1966244535 @default.
- W2108276372 cites W1969233927 @default.
- W2108276372 cites W1970622583 @default.
- W2108276372 cites W1971290197 @default.
- W2108276372 cites W1972668738 @default.
- W2108276372 cites W1977539438 @default.
- W2108276372 cites W1979917024 @default.
- W2108276372 cites W1985969431 @default.
- W2108276372 cites W1986160214 @default.
- W2108276372 cites W1992557609 @default.
- W2108276372 cites W1994238381 @default.
- W2108276372 cites W1996422208 @default.
- W2108276372 cites W1998591442 @default.
- W2108276372 cites W2000984699 @default.
- W2108276372 cites W2001534099 @default.
- W2108276372 cites W2005414062 @default.
- W2108276372 cites W2006551547 @default.
- W2108276372 cites W2009482334 @default.
- W2108276372 cites W2009642901 @default.
- W2108276372 cites W2011058434 @default.
- W2108276372 cites W2023314991 @default.
- W2108276372 cites W2025423015 @default.
- W2108276372 cites W2027342649 @default.
- W2108276372 cites W2032036225 @default.
- W2108276372 cites W2044823518 @default.
- W2108276372 cites W2045101135 @default.
- W2108276372 cites W2045202273 @default.
- W2108276372 cites W2045321923 @default.
- W2108276372 cites W2045885299 @default.
- W2108276372 cites W2051712296 @default.
- W2108276372 cites W2055092476 @default.
- W2108276372 cites W2056519344 @default.
- W2108276372 cites W2057059824 @default.
- W2108276372 cites W2059355578 @default.
- W2108276372 cites W2063755160 @default.
- W2108276372 cites W2063873553 @default.
- W2108276372 cites W2069442173 @default.
- W2108276372 cites W2071837997 @default.
- W2108276372 cites W2077139193 @default.
- W2108276372 cites W2081637154 @default.
- W2108276372 cites W2091140311 @default.
- W2108276372 cites W2092770422 @default.
- W2108276372 cites W2105067846 @default.
- W2108276372 cites W2105277037 @default.
- W2108276372 cites W2107929771 @default.
- W2108276372 cites W2114567767 @default.
- W2108276372 cites W2117117603 @default.
- W2108276372 cites W2117491517 @default.
- W2108276372 cites W2123585553 @default.
- W2108276372 cites W2124727910 @default.
- W2108276372 cites W2126138950 @default.
- W2108276372 cites W2128317669 @default.
- W2108276372 cites W2136462695 @default.
- W2108276372 cites W2137696578 @default.
- W2108276372 cites W2142415596 @default.
- W2108276372 cites W2143962152 @default.
- W2108276372 cites W2151758317 @default.
- W2108276372 cites W2158273823 @default.
- W2108276372 cites W2159367984 @default.
- W2108276372 cites W2162176191 @default.
- W2108276372 cites W2166013785 @default.
- W2108276372 cites W2171108851 @default.
- W2108276372 cites W2178821248 @default.
- W2108276372 cites W2318091769 @default.
- W2108276372 cites W2319295848 @default.
- W2108276372 cites W4240268819 @default.
- W2108276372 doi "https://doi.org/10.1002/aic.14198" @default.
- W2108276372 hasPublicationYear "2013" @default.
- W2108276372 type Work @default.
- W2108276372 sameAs 2108276372 @default.
- W2108276372 citedByCount "14" @default.
- W2108276372 countsByYear W21082763722016 @default.
- W2108276372 countsByYear W21082763722017 @default.
- W2108276372 countsByYear W21082763722018 @default.
- W2108276372 countsByYear W21082763722019 @default.
- W2108276372 countsByYear W21082763722020 @default.
- W2108276372 countsByYear W21082763722021 @default.
- W2108276372 countsByYear W21082763722022 @default.
- W2108276372 crossrefType "journal-article" @default.