FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108281648> ?p ?o ?g. }

• W2108281648 endingPage "5016" @default.
• W2108281648 startingPage "5004" @default.
• W2108281648 abstract "ABSTRACT Competence for genetic transformation in Streptococcus pneumoniae is regulated by a quorum-sensing system encoded by two genetic loci, comCDE and comAB . Additional competence-specific operons, cilA , cilB , cilC , cilD , cilE , cinA-recA , coiA , and cfl , involved in the DNA uptake process and recombination, share an unusual consensus sequence at −10 and −25 in the promoter, which is absent from the promoters of comAB and comCDE . This pattern suggests that a factor regulating transcription of these transformation machinery genes but not involved with comCDE and comAB expression might be an alternative sigma factor. A search for such a global transcriptional regulator was begun by purifying pneumococcal RNA polymerase holoenzyme. In preparations from competent pneumococcal cultures a protein which seemed to be responsible for cilA transcription in vitro was identified. The corresponding gene was identified and found to be present in two copies, designated comX1 and comX2 , located adjacent to two of the repeated rRNA operons. Expression of transformation machinery operons, such as cilA , cilD , cilE , and cfl , but not that of the quorum-sensing operons comAB and comCDE , was shown to depend on comX , while comX expression depended on ComE but not on ComX itself. We conclude that the factor is a competence-specific global transcription modulator which links quorum-sensing information transduced to ComE to competence and propose that it acts as an alternate sigma factor. We also report that comAB and comCDE are not sufficient for shutoff of competence-stimulating peptide-induced gene expression nor for the subsequent refractory period, suggesting that these phenomena depend on one or more ComX-dependent genes." @default.
• W2108281648 created "2016-06-24" @default.
• W2108281648 creator A5045588156 @default.
• W2108281648 creator A5070272340 @default.
• W2108281648 date "1999-08-15" @default.
• W2108281648 modified "2023-10-18" @default.
• W2108281648 title "Identification of a New Regulator inStreptococcus pneumoniae Linking Quorum Sensing to Competence for Genetic Transformation" @default.
• W2108281648 cites W1518272160 @default.
• W2108281648 cites W1560298788 @default.
• W2108281648 cites W1592912115 @default.
• W2108281648 cites W1624615484 @default.
• W2108281648 cites W1910498876 @default.
• W2108281648 cites W1986198902 @default.
• W2108281648 cites W1994393857 @default.
• W2108281648 cites W2011747306 @default.
• W2108281648 cites W2013437656 @default.
• W2108281648 cites W2020334067 @default.
• W2108281648 cites W2028595806 @default.
• W2108281648 cites W2030893445 @default.
• W2108281648 cites W2036659415 @default.
• W2108281648 cites W2036944766 @default.
• W2108281648 cites W2038260184 @default.
• W2108281648 cites W2042050496 @default.
• W2108281648 cites W2043932025 @default.
• W2108281648 cites W2044618828 @default.
• W2108281648 cites W2047929024 @default.
• W2108281648 cites W2048863389 @default.
• W2108281648 cites W2049800941 @default.
• W2108281648 cites W2066754826 @default.
• W2108281648 cites W2068166540 @default.
• W2108281648 cites W2070756319 @default.
• W2108281648 cites W2074726414 @default.
• W2108281648 cites W2076548586 @default.
• W2108281648 cites W2080263535 @default.
• W2108281648 cites W2081211831 @default.
• W2108281648 cites W2083901472 @default.
• W2108281648 cites W2085920858 @default.
• W2108281648 cites W2094176470 @default.
• W2108281648 cites W2107825020 @default.
• W2108281648 cites W2109889137 @default.
• W2108281648 cites W2114837947 @default.
• W2108281648 cites W2123974237 @default.
• W2108281648 cites W2130108985 @default.
• W2108281648 cites W2146156845 @default.
• W2108281648 cites W2146763898 @default.
• W2108281648 cites W2152882631 @default.
• W2108281648 cites W2159094764 @default.
• W2108281648 cites W2163481720 @default.
• W2108281648 cites W2164013467 @default.
• W2108281648 cites W2172250295 @default.
• W2108281648 cites W4241640895 @default.
• W2108281648 doi "https://doi.org/10.1128/jb.181.16.5004-5016.1999" @default.
• W2108281648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/93990" @default.
• W2108281648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10438773" @default.
• W2108281648 hasPublicationYear "1999" @default.
• W2108281648 type Work @default.
• W2108281648 sameAs 2108281648 @default.
• W2108281648 citedByCount "294" @default.
• W2108281648 countsByYear W21082816482012 @default.
• W2108281648 countsByYear W21082816482013 @default.
• W2108281648 countsByYear W21082816482014 @default.
• W2108281648 countsByYear W21082816482015 @default.
• W2108281648 countsByYear W21082816482016 @default.
• W2108281648 countsByYear W21082816482017 @default.
• W2108281648 countsByYear W21082816482018 @default.
• W2108281648 countsByYear W21082816482019 @default.
• W2108281648 countsByYear W21082816482020 @default.
• W2108281648 countsByYear W21082816482021 @default.
• W2108281648 countsByYear W21082816482022 @default.
• W2108281648 countsByYear W21082816482023 @default.
• W2108281648 crossrefType "journal-article" @default.
• W2108281648 hasAuthorship W2108281648A5045588156 @default.
• W2108281648 hasAuthorship W2108281648A5070272340 @default.
• W2108281648 hasBestOaLocation W21082816481 @default.
• W2108281648 hasConcept C101762097 @default.
• W2108281648 hasConcept C104317684 @default.
• W2108281648 hasConcept C118687296 @default.
• W2108281648 hasConcept C138885662 @default.
• W2108281648 hasConcept C150194340 @default.
• W2108281648 hasConcept C165864922 @default.
• W2108281648 hasConcept C179926584 @default.
• W2108281648 hasConcept C203075996 @default.
• W2108281648 hasConcept C41895202 @default.
• W2108281648 hasConcept C47319516 @default.
• W2108281648 hasConcept C54355233 @default.
• W2108281648 hasConcept C547475151 @default.
• W2108281648 hasConcept C60987743 @default.
• W2108281648 hasConcept C86339819 @default.
• W2108281648 hasConcept C86803240 @default.
• W2108281648 hasConceptScore W2108281648C101762097 @default.
• W2108281648 hasConceptScore W2108281648C104317684 @default.
• W2108281648 hasConceptScore W2108281648C118687296 @default.
• W2108281648 hasConceptScore W2108281648C138885662 @default.
• W2108281648 hasConceptScore W2108281648C150194340 @default.
• W2108281648 hasConceptScore W2108281648C165864922 @default.
• W2108281648 hasConceptScore W2108281648C179926584 @default.
• W2108281648 hasConceptScore W2108281648C203075996 @default.
• W2108281648 hasConceptScore W2108281648C41895202 @default.

• next