Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108281657> ?p ?o ?g. }
- W2108281657 endingPage "603" @default.
- W2108281657 startingPage "589" @default.
- W2108281657 abstract "Importance of the field: Millions of people receive annually an internal device aimed to repair or reconstruct damaged bone, and different therapeutic moieties are administered during or after surgery generally using systemic routes. The local administration of those moieties using in situ drug-eluting devices emerges as an alternative to minimize undesired side effects in healthy tissues, optimize the amount of drug needed, and reduce the costs.Areas covered in this review: In vitro and in vivo published evidence regarding the performance of internally implantable drug-loaded biomedical devices for traumatology and orthopedic surgery are reviewed in this article, the problems that are encountered, and the main challenges in the development of a new generation of devices.What the reader will gain: An insight of past and current efforts to control the rate of drug release from devices, as well as the requirements that future developments may fulfill, such as responding ‘on demand’ after biological signaling or communicating the device with the exterior.Take home message: The main drawback for proper design of devices having improved capabilities mainly remains in the lack of understanding with regards to the complex regulation of physiopathological mechanisms and the thermodynamics at the interface between the implant surface and the surrounding tissue. The potential toxicity and risk versus benefits of any new drug-eluting device need to be evaluated carefully." @default.
- W2108281657 created "2016-06-24" @default.
- W2108281657 creator A5019717738 @default.
- W2108281657 creator A5027484410 @default.
- W2108281657 creator A5054888512 @default.
- W2108281657 date "2010-03-15" @default.
- W2108281657 modified "2023-10-10" @default.
- W2108281657 title "Drug delivery from internally implanted biomedical devices used in traumatology and in orthopedic surgery" @default.
- W2108281657 cites W1579096275 @default.
- W2108281657 cites W1713223441 @default.
- W2108281657 cites W1842787690 @default.
- W2108281657 cites W1921770897 @default.
- W2108281657 cites W1966690336 @default.
- W2108281657 cites W1967469313 @default.
- W2108281657 cites W1971359976 @default.
- W2108281657 cites W1971972063 @default.
- W2108281657 cites W1974729986 @default.
- W2108281657 cites W1975548285 @default.
- W2108281657 cites W1982947171 @default.
- W2108281657 cites W1983332596 @default.
- W2108281657 cites W1988664023 @default.
- W2108281657 cites W1988728595 @default.
- W2108281657 cites W1989764287 @default.
- W2108281657 cites W1990076650 @default.
- W2108281657 cites W1991976751 @default.
- W2108281657 cites W1992409865 @default.
- W2108281657 cites W1994486206 @default.
- W2108281657 cites W1994942983 @default.
- W2108281657 cites W1995344681 @default.
- W2108281657 cites W1996032252 @default.
- W2108281657 cites W1997484255 @default.
- W2108281657 cites W1998484607 @default.
- W2108281657 cites W1998792752 @default.
- W2108281657 cites W1999869481 @default.
- W2108281657 cites W2003144647 @default.
- W2108281657 cites W2004318478 @default.
- W2108281657 cites W2006872498 @default.
- W2108281657 cites W2009172607 @default.
- W2108281657 cites W2016461317 @default.
- W2108281657 cites W2018855840 @default.
- W2108281657 cites W2028049079 @default.
- W2108281657 cites W2028216922 @default.
- W2108281657 cites W2033329981 @default.
- W2108281657 cites W2033811490 @default.
- W2108281657 cites W2035045805 @default.
- W2108281657 cites W2035570988 @default.
- W2108281657 cites W2039249790 @default.
- W2108281657 cites W2042664453 @default.
- W2108281657 cites W2047438206 @default.
- W2108281657 cites W2054145689 @default.
- W2108281657 cites W2057067590 @default.
- W2108281657 cites W2057798989 @default.
- W2108281657 cites W2058638230 @default.
- W2108281657 cites W2059166356 @default.
- W2108281657 cites W2061073363 @default.
- W2108281657 cites W2062228001 @default.
- W2108281657 cites W2062856622 @default.
- W2108281657 cites W2062896155 @default.
- W2108281657 cites W2063605214 @default.
- W2108281657 cites W2064717346 @default.
- W2108281657 cites W2066241710 @default.
- W2108281657 cites W2068283751 @default.
- W2108281657 cites W2068645319 @default.
- W2108281657 cites W2073034375 @default.
- W2108281657 cites W2073617358 @default.
- W2108281657 cites W2076260563 @default.
- W2108281657 cites W2077042278 @default.
- W2108281657 cites W2077457317 @default.
- W2108281657 cites W2078089143 @default.
- W2108281657 cites W2080433928 @default.
- W2108281657 cites W2086979522 @default.
- W2108281657 cites W2092744085 @default.
- W2108281657 cites W2094920892 @default.
- W2108281657 cites W2100664422 @default.
- W2108281657 cites W2103241039 @default.
- W2108281657 cites W2104954144 @default.
- W2108281657 cites W2108421027 @default.
- W2108281657 cites W2118471200 @default.
- W2108281657 cites W2124836962 @default.
- W2108281657 cites W2125603952 @default.
- W2108281657 cites W2133269892 @default.
- W2108281657 cites W2137219842 @default.
- W2108281657 cites W2137803355 @default.
- W2108281657 cites W2139580016 @default.
- W2108281657 cites W2140616239 @default.
- W2108281657 cites W2144358022 @default.
- W2108281657 cites W2150819459 @default.
- W2108281657 cites W2156069752 @default.
- W2108281657 cites W2163440116 @default.
- W2108281657 cites W2170908991 @default.
- W2108281657 cites W2223784662 @default.
- W2108281657 cites W2291088695 @default.
- W2108281657 cites W35430915 @default.
- W2108281657 cites W415697437 @default.
- W2108281657 cites W4376999406 @default.
- W2108281657 doi "https://doi.org/10.1517/17425241003671544" @default.
- W2108281657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20230306" @default.
- W2108281657 hasPublicationYear "2010" @default.