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• W2108283508 endingPage "1287" @default.
• W2108283508 startingPage "1278" @default.
• W2108283508 abstract "Cervical epithelia have numerous functions that include proliferation, differentiation, maintenance of fluid balance, protection from environmental hazards, and paracellular transport of solutes via tight junctions (TJs). Epithelial functions must be tightly regulated during pregnancy and parturition as the cervix undergoes extensive growth and remodeling. This study evaluated TJ proteins, as well as markers of epithelial cell differentiation in normal and cervical ripening defective mice to gain insights into how the permeability barrier is regulated during pregnancy and parturition. Although numerous TJ proteins are expressed in the nonpregnant cervix, claudins 1 and 2 are temporally regulated in pregnancy. Claudin 1 mRNA expression is increased, whereas claudin 2 expression declines. The cellular localization of claudin 1 shifts at the end of pregnancy (gestation d 18.75) to the plasma membrane in a lattice pattern, consistent with TJs in the apical cells. The timing of claudin 1-enriched TJs coincides with initiation of terminal differentiation of cervical squamous epithelia as evidenced by the increased expression of genes by differentiated epithelia late on gestation d 18. The cervical ripening defective steroid 5alpha-reductase type 1 deficient mouse, which has an elevated local progesterone concentration, also has aberrant claudin 1 and 2 expressions, fails to form claudin 1-enriched TJs, and lacks normal expression of genes involved in epithelial terminal differentiation. These data suggest that changes in permeability barrier properties during cervical ripening are, in part, negatively regulated by progesterone, and that dynamic changes in barrier properties of the cervix occur during pregnancy and parturition." @default.
• W2108283508 created "2016-06-24" @default.
• W2108283508 creator A5020426435 @default.
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• W2108283508 creator A5058537452 @default.
• W2108283508 creator A5069320945 @default.
• W2108283508 date "2007-03-01" @default.
• W2108283508 modified "2023-10-16" @default.
• W2108283508 title "Dynamic Changes in the Cervical Epithelial Tight Junction Complex and Differentiation Occur during Cervical Ripening and Parturition" @default.
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• W2108283508 doi "https://doi.org/10.1210/en.2006-0851" @default.
• W2108283508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17138657" @default.
• W2108283508 hasPublicationYear "2007" @default.
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