FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108286900> ?p ?o ?g. }

• W2108286900 endingPage "880" @default.
• W2108286900 startingPage "876" @default.
• W2108286900 abstract "BackgroundPain on injection of propofol is unpleasant. We hypothesized that propofol infusion pain might be prevented by infusing remifentanil before starting the propofol infusion in a clinical setting where target-controlled infusions (TCI) of both drugs were used. A prospective, randomized, double-blind, placebo-controlled trial was performed to determine the effect-site concentration (Ce) of remifentanil to prevent the pain without producing complications.MethodsA total of 128 patients undergoing general surgery were randomly allocated to receive normal saline (control) or remifentanil to a target Ce of 2 ng ml−1 (R2), 4 ng ml−1 (R4), or 6 ng ml−1 (R6) administered via TCI. After the target Ce was achieved, the infusion of propofol was started. Remifentanil-related complications were assessed during the remifentanil infusion, and pain caused by propofol was evaluated using a four-point scale during the propofol infusion.ResultsThe incidence of pain was significantly lower in Groups R4 and R6 than in the control and R2 groups (12/32 and 6/31 vs 26/31 and 25/32, respectively, P<0.001). Pain was less severe in Groups R4 and R6 than in the control and R2 groups (P<0.001). However, both incidence and severity of pain were not different between Groups R4 and R6. No significant complications were observed during the study.ConclusionsDuring induction of anaesthesia with TCI of propofol and remifentanil, a significant reduction in propofol infusion pain was achieved without significant complications by prior administration of remifentanil at a target Ce of 4 ng ml−1. Pain on injection of propofol is unpleasant. We hypothesized that propofol infusion pain might be prevented by infusing remifentanil before starting the propofol infusion in a clinical setting where target-controlled infusions (TCI) of both drugs were used. A prospective, randomized, double-blind, placebo-controlled trial was performed to determine the effect-site concentration (Ce) of remifentanil to prevent the pain without producing complications. A total of 128 patients undergoing general surgery were randomly allocated to receive normal saline (control) or remifentanil to a target Ce of 2 ng ml−1 (R2), 4 ng ml−1 (R4), or 6 ng ml−1 (R6) administered via TCI. After the target Ce was achieved, the infusion of propofol was started. Remifentanil-related complications were assessed during the remifentanil infusion, and pain caused by propofol was evaluated using a four-point scale during the propofol infusion. The incidence of pain was significantly lower in Groups R4 and R6 than in the control and R2 groups (12/32 and 6/31 vs 26/31 and 25/32, respectively, P<0.001). Pain was less severe in Groups R4 and R6 than in the control and R2 groups (P<0.001). However, both incidence and severity of pain were not different between Groups R4 and R6. No significant complications were observed during the study. During induction of anaesthesia with TCI of propofol and remifentanil, a significant reduction in propofol infusion pain was achieved without significant complications by prior administration of remifentanil at a target Ce of 4 ng ml−1." @default.
• W2108286900 created "2016-06-24" @default.
• W2108286900 creator A5040936156 @default.
• W2108286900 creator A5047565589 @default.
• W2108286900 creator A5081663731 @default.
• W2108286900 date "2007-12-01" @default.
• W2108286900 modified "2023-09-27" @default.
• W2108286900 title "Reduction of pain during induction with target-controlled propofol and remifentanil" @default.
• W2108286900 cites W1595822733 @default.
• W2108286900 cites W1969931398 @default.
• W2108286900 cites W1975848917 @default.
• W2108286900 cites W1988207262 @default.
• W2108286900 cites W2009197424 @default.
• W2108286900 cites W2017308006 @default.
• W2108286900 cites W2040195798 @default.
• W2108286900 cites W2055704041 @default.
• W2108286900 cites W2056954016 @default.
• W2108286900 cites W2083534294 @default.
• W2108286900 cites W2086489691 @default.
• W2108286900 cites W2086570641 @default.
• W2108286900 cites W2089670500 @default.
• W2108286900 cites W2126155630 @default.
• W2108286900 cites W2134814334 @default.
• W2108286900 cites W2143926567 @default.
• W2108286900 cites W2488700677 @default.
• W2108286900 cites W4240323919 @default.
• W2108286900 cites W4244667188 @default.
• W2108286900 doi "https://doi.org/10.1093/bja/aem293" @default.
• W2108286900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18006530" @default.
• W2108286900 hasPublicationYear "2007" @default.
• W2108286900 type Work @default.
• W2108286900 sameAs 2108286900 @default.
• W2108286900 citedByCount "37" @default.
• W2108286900 countsByYear W21082869002012 @default.
• W2108286900 countsByYear W21082869002013 @default.
• W2108286900 countsByYear W21082869002014 @default.
• W2108286900 countsByYear W21082869002015 @default.
• W2108286900 countsByYear W21082869002016 @default.
• W2108286900 countsByYear W21082869002018 @default.
• W2108286900 countsByYear W21082869002019 @default.
• W2108286900 countsByYear W21082869002020 @default.
• W2108286900 countsByYear W21082869002022 @default.
• W2108286900 countsByYear W21082869002023 @default.
• W2108286900 crossrefType "journal-article" @default.
• W2108286900 hasAuthorship W2108286900A5040936156 @default.
• W2108286900 hasAuthorship W2108286900A5047565589 @default.
• W2108286900 hasAuthorship W2108286900A5081663731 @default.
• W2108286900 hasBestOaLocation W21082869001 @default.
• W2108286900 hasConcept C142724271 @default.
• W2108286900 hasConcept C204787440 @default.
• W2108286900 hasConcept C27081682 @default.
• W2108286900 hasConcept C2776277131 @default.
• W2108286900 hasConcept C2777397205 @default.
• W2108286900 hasConcept C2778891214 @default.
• W2108286900 hasConcept C3019240266 @default.
• W2108286900 hasConcept C42219234 @default.
• W2108286900 hasConcept C71924100 @default.
• W2108286900 hasConceptScore W2108286900C142724271 @default.
• W2108286900 hasConceptScore W2108286900C204787440 @default.
• W2108286900 hasConceptScore W2108286900C27081682 @default.
• W2108286900 hasConceptScore W2108286900C2776277131 @default.
• W2108286900 hasConceptScore W2108286900C2777397205 @default.
• W2108286900 hasConceptScore W2108286900C2778891214 @default.
• W2108286900 hasConceptScore W2108286900C3019240266 @default.
• W2108286900 hasConceptScore W2108286900C42219234 @default.
• W2108286900 hasConceptScore W2108286900C71924100 @default.
• W2108286900 hasIssue "6" @default.
• W2108286900 hasLocation W21082869001 @default.
• W2108286900 hasLocation W21082869002 @default.
• W2108286900 hasLocation W21082869003 @default.
• W2108286900 hasOpenAccess W2108286900 @default.
• W2108286900 hasPrimaryLocation W21082869001 @default.
• W2108286900 hasRelatedWork W2012346267 @default.
• W2108286900 hasRelatedWork W2356535322 @default.
• W2108286900 hasRelatedWork W2360956990 @default.
• W2108286900 hasRelatedWork W2370705670 @default.
• W2108286900 hasRelatedWork W2371322798 @default.
• W2108286900 hasRelatedWork W2373170717 @default.
• W2108286900 hasRelatedWork W2384521401 @default.
• W2108286900 hasRelatedWork W2390399741 @default.
• W2108286900 hasRelatedWork W2753453059 @default.
• W2108286900 hasRelatedWork W2988764929 @default.
• W2108286900 hasVolume "99" @default.
• W2108286900 isParatext "false" @default.
• W2108286900 isRetracted "false" @default.
• W2108286900 magId "2108286900" @default.
• W2108286900 workType "article" @default.