Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108289516> ?p ?o ?g. }
- W2108289516 endingPage "1368" @default.
- W2108289516 startingPage "1358" @default.
- W2108289516 abstract "The limited antioxidative capacity of the embryo and fetus may increase their risk for cancer initiation and/or promotion by reactive oxygen species (ROS)-mediated oxidative DNA damage and/or signaling. To determine if cancer can originate in utero , a high dietary dose of the antioxidant vitamin E (VE) (10% dl -α-tocopherol-acetate) was given to cancer-prone p53 knockout mice throughout pregnancy. Although reducing fetal death ( P < 0.05), in utero exposure to VE enhanced postnatal tumorigenesis in both +/− ( P < 0.04) and −/− ( P < 0.0008) p53-deficient offspring. VE did not alter maternal weights, offspring p53 genotypic distribution or tumor spectrum. Constitutive embryonic DNA oxidation in untreated −/− p53 embryos [gestational day (GD) 13] was higher than in +/− and +/+ p53 littermates ( P < 0.05). VE reduced DNA oxidation in −/− p53 embryos ( P < 0.05) without affecting +/− and +/+ p53 littermates. VE had contrasting, tissue-dependent effects on fetal (GD 19) DNA oxidation, with reductions in −/− and +/− p53-deficient fetal brains ( P < 0.01), increases in skin ( P < 0.05) and no effect in liver and thymus. The 250-fold increase in dietary VE levels produced only 1.6–6.3-fold, tissue-dependent increases in tissue concentrations. The greatest increase, in fetal skin, correlated with increased DNA oxidation in that tissue in −/− and +/− p53-deficient fetuses and enhanced tumorigenesis in these genotypes. These results show that some cancers may originate in utero and the risk can be enhanced by embryonic and fetal exposure to high dietary levels of VE. The elevated DNA oxidation in some tissues of untreated −/− p53 offspring suggests that ROS may contribute to their higher baseline tumor incidence. The limited and tissue-dependent disposition of VE indicates substantial conceptal regulation. The similarly selective and contrasting effects of VE on DNA oxidation may contribute to its controversial protective efficacy and suggest that its effects on tumorigenesis are cell-specific, possibly in high doses involving a pro-oxidative mechanism." @default.
- W2108289516 created "2016-06-24" @default.
- W2108289516 creator A5072894260 @default.
- W2108289516 creator A5084437097 @default.
- W2108289516 date "2006-01-09" @default.
- W2108289516 modified "2023-09-25" @default.
- W2108289516 title "Enhanced tumorigenesis in p53 knockout mice exposed in utero to high-dose vitamin E" @default.
- W2108289516 cites W1490172606 @default.
- W2108289516 cites W1535461485 @default.
- W2108289516 cites W1881393103 @default.
- W2108289516 cites W1937902294 @default.
- W2108289516 cites W1940935006 @default.
- W2108289516 cites W1941294128 @default.
- W2108289516 cites W1951278183 @default.
- W2108289516 cites W1963650188 @default.
- W2108289516 cites W1964901186 @default.
- W2108289516 cites W1966147045 @default.
- W2108289516 cites W1967487924 @default.
- W2108289516 cites W1976254862 @default.
- W2108289516 cites W1977788913 @default.
- W2108289516 cites W1984656331 @default.
- W2108289516 cites W1986773920 @default.
- W2108289516 cites W1986795920 @default.
- W2108289516 cites W1997225346 @default.
- W2108289516 cites W1999444895 @default.
- W2108289516 cites W2000068361 @default.
- W2108289516 cites W2009187135 @default.
- W2108289516 cites W2012919508 @default.
- W2108289516 cites W2013473138 @default.
- W2108289516 cites W2013873616 @default.
- W2108289516 cites W2015309291 @default.
- W2108289516 cites W2017116286 @default.
- W2108289516 cites W2026637815 @default.
- W2108289516 cites W2027574725 @default.
- W2108289516 cites W2030305324 @default.
- W2108289516 cites W2031052102 @default.
- W2108289516 cites W2031737798 @default.
- W2108289516 cites W2032693719 @default.
- W2108289516 cites W2036128774 @default.
- W2108289516 cites W2041306334 @default.
- W2108289516 cites W2041621528 @default.
- W2108289516 cites W2046303138 @default.
- W2108289516 cites W2047447331 @default.
- W2108289516 cites W2048253418 @default.
- W2108289516 cites W2052492066 @default.
- W2108289516 cites W2053076131 @default.
- W2108289516 cites W2054807774 @default.
- W2108289516 cites W2055312920 @default.
- W2108289516 cites W2055640831 @default.
- W2108289516 cites W2055943681 @default.
- W2108289516 cites W2056079046 @default.
- W2108289516 cites W2056228772 @default.
- W2108289516 cites W2060909573 @default.
- W2108289516 cites W2061019838 @default.
- W2108289516 cites W2061242671 @default.
- W2108289516 cites W2066137233 @default.
- W2108289516 cites W2067092405 @default.
- W2108289516 cites W2068349898 @default.
- W2108289516 cites W2079822311 @default.
- W2108289516 cites W2084462922 @default.
- W2108289516 cites W2085826212 @default.
- W2108289516 cites W2088740611 @default.
- W2108289516 cites W2089537636 @default.
- W2108289516 cites W2091367216 @default.
- W2108289516 cites W2091861523 @default.
- W2108289516 cites W2092320337 @default.
- W2108289516 cites W2095405591 @default.
- W2108289516 cites W2109543726 @default.
- W2108289516 cites W2111806753 @default.
- W2108289516 cites W2113388598 @default.
- W2108289516 cites W2115300678 @default.
- W2108289516 cites W2117930748 @default.
- W2108289516 cites W2123632312 @default.
- W2108289516 cites W2124139409 @default.
- W2108289516 cites W2126679757 @default.
- W2108289516 cites W2127242142 @default.
- W2108289516 cites W2140085669 @default.
- W2108289516 cites W2140126848 @default.
- W2108289516 cites W2140220133 @default.
- W2108289516 cites W2158171963 @default.
- W2108289516 cites W2170179311 @default.
- W2108289516 cites W2334246894 @default.
- W2108289516 cites W2356484699 @default.
- W2108289516 cites W2410177573 @default.
- W2108289516 cites W4242257292 @default.
- W2108289516 cites W2076739326 @default.
- W2108289516 doi "https://doi.org/10.1093/carcin/bgi325" @default.
- W2108289516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16401638" @default.
- W2108289516 hasPublicationYear "2006" @default.
- W2108289516 type Work @default.
- W2108289516 sameAs 2108289516 @default.
- W2108289516 citedByCount "19" @default.
- W2108289516 countsByYear W21082895162012 @default.
- W2108289516 countsByYear W21082895162013 @default.
- W2108289516 countsByYear W21082895162014 @default.
- W2108289516 countsByYear W21082895162018 @default.
- W2108289516 countsByYear W21082895162019 @default.
- W2108289516 countsByYear W21082895162022 @default.