FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108290734> ?p ?o ?g. }

• W2108290734 endingPage "1279" @default.
• W2108290734 startingPage "1274" @default.
• W2108290734 abstract "Based on the structures of NVP-DPP728 (1) and NVP-LAF237 (Vildagliptin, 2), three series of DPP-IV inhibitors were synthesized by linking substituted anilines, benzylamines, and phenylethylamines to (2S)-cyanopyrrolidine through a linker. More than 20 compounds were evaluated for their in vitro DPP-IV inhibition and selectivity profile over DPP-II, DPP8, and FAP enzymes. Selected compounds 5f and 7i showed in vivo plasma DPP-IV inhibition and inhibited glucose excursion in OGTT after oral administration in Wistar rats. Compound 5f (DPP-IV IC50 = 116 nM) has the potential for development as antidiabetic agent." @default.
• W2108290734 created "2016-06-24" @default.
• W2108290734 creator A5001291488 @default.
• W2108290734 creator A5002576867 @default.
• W2108290734 creator A5004171019 @default.
• W2108290734 creator A5016860933 @default.
• W2108290734 creator A5017391108 @default.
• W2108290734 creator A5018084988 @default.
• W2108290734 creator A5022257097 @default.
• W2108290734 creator A5028462736 @default.
• W2108290734 creator A5032248748 @default.
• W2108290734 creator A5034708145 @default.
• W2108290734 creator A5036592907 @default.
• W2108290734 creator A5061434695 @default.
• W2108290734 creator A5063679299 @default.
• W2108290734 creator A5066133791 @default.
• W2108290734 creator A5076078717 @default.
• W2108290734 creator A5088705788 @default.
• W2108290734 date "2007-03-01" @default.
• W2108290734 modified "2023-10-16" @default.
• W2108290734 title "3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes" @default.
• W2108290734 cites W1964212912 @default.
• W2108290734 cites W1965799612 @default.
• W2108290734 cites W1975767684 @default.
• W2108290734 cites W1977679840 @default.
• W2108290734 cites W1991565451 @default.
• W2108290734 cites W1993287695 @default.
• W2108290734 cites W2012437459 @default.
• W2108290734 cites W2049222364 @default.
• W2108290734 cites W2049323977 @default.
• W2108290734 cites W2083473802 @default.
• W2108290734 cites W2084363158 @default.
• W2108290734 cites W2104763836 @default.
• W2108290734 cites W2109157463 @default.
• W2108290734 cites W2123629330 @default.
• W2108290734 cites W2141727442 @default.
• W2108290734 cites W2145884719 @default.
• W2108290734 cites W2146232529 @default.
• W2108290734 cites W2160895888 @default.
• W2108290734 cites W4230178491 @default.
• W2108290734 doi "https://doi.org/10.1016/j.bmcl.2006.12.019" @default.
• W2108290734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17194587" @default.
• W2108290734 hasPublicationYear "2007" @default.
• W2108290734 type Work @default.
• W2108290734 sameAs 2108290734 @default.
• W2108290734 citedByCount "11" @default.
• W2108290734 countsByYear W21082907342012 @default.
• W2108290734 countsByYear W21082907342013 @default.
• W2108290734 countsByYear W21082907342016 @default.
• W2108290734 countsByYear W21082907342019 @default.
• W2108290734 countsByYear W21082907342021 @default.
• W2108290734 crossrefType "journal-article" @default.
• W2108290734 hasAuthorship W2108290734A5001291488 @default.
• W2108290734 hasAuthorship W2108290734A5002576867 @default.
• W2108290734 hasAuthorship W2108290734A5004171019 @default.
• W2108290734 hasAuthorship W2108290734A5016860933 @default.
• W2108290734 hasAuthorship W2108290734A5017391108 @default.
• W2108290734 hasAuthorship W2108290734A5018084988 @default.
• W2108290734 hasAuthorship W2108290734A5022257097 @default.
• W2108290734 hasAuthorship W2108290734A5028462736 @default.
• W2108290734 hasAuthorship W2108290734A5032248748 @default.
• W2108290734 hasAuthorship W2108290734A5034708145 @default.
• W2108290734 hasAuthorship W2108290734A5036592907 @default.
• W2108290734 hasAuthorship W2108290734A5061434695 @default.
• W2108290734 hasAuthorship W2108290734A5063679299 @default.
• W2108290734 hasAuthorship W2108290734A5066133791 @default.
• W2108290734 hasAuthorship W2108290734A5076078717 @default.
• W2108290734 hasAuthorship W2108290734A5088705788 @default.
• W2108290734 hasConcept C111919701 @default.
• W2108290734 hasConcept C118792377 @default.
• W2108290734 hasConcept C134018914 @default.
• W2108290734 hasConcept C150903083 @default.
• W2108290734 hasConcept C156490143 @default.
• W2108290734 hasConcept C161790260 @default.
• W2108290734 hasConcept C181199279 @default.
• W2108290734 hasConcept C185592680 @default.
• W2108290734 hasConcept C202751555 @default.
• W2108290734 hasConcept C207001950 @default.
• W2108290734 hasConcept C2776453732 @default.
• W2108290734 hasConcept C2776980637 @default.
• W2108290734 hasConcept C2777180221 @default.
• W2108290734 hasConcept C2777752497 @default.
• W2108290734 hasConcept C2780557392 @default.
• W2108290734 hasConcept C41008148 @default.
• W2108290734 hasConcept C55493867 @default.
• W2108290734 hasConcept C555293320 @default.
• W2108290734 hasConcept C71240020 @default.
• W2108290734 hasConcept C71924100 @default.
• W2108290734 hasConcept C86803240 @default.
• W2108290734 hasConcept C98274493 @default.
• W2108290734 hasConceptScore W2108290734C111919701 @default.
• W2108290734 hasConceptScore W2108290734C118792377 @default.
• W2108290734 hasConceptScore W2108290734C134018914 @default.
• W2108290734 hasConceptScore W2108290734C150903083 @default.
• W2108290734 hasConceptScore W2108290734C156490143 @default.
• W2108290734 hasConceptScore W2108290734C161790260 @default.
• W2108290734 hasConceptScore W2108290734C181199279 @default.
• W2108290734 hasConceptScore W2108290734C185592680 @default.

• next