FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108290804> ?p ?o ?g. }

• W2108290804 endingPage "G67" @default.
• W2108290804 startingPage "G60" @default.
• W2108290804 abstract "Nitric oxide (NO) is suggested to play a role in liver injury elicited by acetaminophen (APAP). Hepatic microcirculatory dysfunction also is reported to contribute to the development of the injury. As a result, the role of NO in hepatic microcirculatory alterations in response to APAP was examined in mice by in vivo microscopy. A selective inducible NO synthase (iNOS) inhibitor,l-N6-(1-iminoethyl)-lysine (L-NIL), or a nonselective NOS inhibitor, NG-nitro-l-arginine methyl ester (L-NAME), was intraperitoneally administered to animals 10 min before APAP gavage. L-NIL suppressed raised alanine aminotransferase (ALT) values 6 h after APAP, whereas L-NAME increased those 1.7-fold. Increased ALT levels were associated with hepatic expression of iNOS. L-NIL, but not L-NAME, reduced the expression. APAP caused a reduction (20%) in the numbers of perfused sinusoids. L-NIL restored the sinusoidal perfusion, but L-NAME was ineffective. APAP increased the area occupied by infiltrated erythrocytes into the extrasinusoidal space. L-NIL tended to minimize this infiltration, whereas L-NAME further enhanced it. APAP caused an increase (1.5-fold) in Kupffer cell phagocytic activity. This activity in response to APAP was blunted by L-NIL, whereas L-NAME further elevated it. L-NIL suppressed APAP-induced decreases in hepatic glutathione levels. These results suggest that NO derived from iNOS contributes to APAP-induced parenchymal cell injury and hepatic microcirculatory disturbances. L-NIL exerts preventive effects on the liver injury partly by inhibiting APAP bioactivation. In contrast, NO derived from constitutive isoforms of NOS exerts a protective role in liver microcirculation against APAP intoxication and thereby minimizes liver injury." @default.
• W2108290804 created "2016-06-24" @default.
• W2108290804 creator A5011504486 @default.
• W2108290804 creator A5022758679 @default.
• W2108290804 creator A5035114536 @default.
• W2108290804 creator A5079413998 @default.
• W2108290804 date "2004-01-01" @default.
• W2108290804 modified "2023-10-17" @default.
• W2108290804 title "Role of nitric oxide in hepatic microvascular injury elicited by acetaminophen in mice" @default.
• W2108290804 cites W1528220495 @default.
• W2108290804 cites W1967245379 @default.
• W2108290804 cites W1967396537 @default.
• W2108290804 cites W1986378496 @default.
• W2108290804 cites W1991844778 @default.
• W2108290804 cites W1995744241 @default.
• W2108290804 cites W2002427790 @default.
• W2108290804 cites W2009609856 @default.
• W2108290804 cites W2018685529 @default.
• W2108290804 cites W2022270708 @default.
• W2108290804 cites W2029491963 @default.
• W2108290804 cites W2033635345 @default.
• W2108290804 cites W2039818533 @default.
• W2108290804 cites W2040893865 @default.
• W2108290804 cites W2055420058 @default.
• W2108290804 cites W2058137293 @default.
• W2108290804 cites W2069585529 @default.
• W2108290804 cites W2078036072 @default.
• W2108290804 cites W2079736357 @default.
• W2108290804 cites W2135570727 @default.
• W2108290804 cites W2142754219 @default.
• W2108290804 cites W2145560274 @default.
• W2108290804 cites W2148384239 @default.
• W2108290804 cites W2155970781 @default.
• W2108290804 cites W2165432213 @default.
• W2108290804 cites W2174238176 @default.
• W2108290804 cites W2238405015 @default.
• W2108290804 cites W2343171406 @default.
• W2108290804 cites W363782758 @default.
• W2108290804 cites W4298997209 @default.
• W2108290804 doi "https://doi.org/10.1152/ajpgi.00217.2003" @default.
• W2108290804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12969830" @default.
• W2108290804 hasPublicationYear "2004" @default.
• W2108290804 type Work @default.
• W2108290804 sameAs 2108290804 @default.
• W2108290804 citedByCount "64" @default.
• W2108290804 countsByYear W21082908042012 @default.
• W2108290804 countsByYear W21082908042013 @default.
• W2108290804 countsByYear W21082908042014 @default.
• W2108290804 countsByYear W21082908042015 @default.
• W2108290804 countsByYear W21082908042016 @default.
• W2108290804 countsByYear W21082908042017 @default.
• W2108290804 countsByYear W21082908042018 @default.
• W2108290804 countsByYear W21082908042019 @default.
• W2108290804 countsByYear W21082908042020 @default.
• W2108290804 countsByYear W21082908042021 @default.
• W2108290804 countsByYear W21082908042022 @default.
• W2108290804 countsByYear W21082908042023 @default.
• W2108290804 crossrefType "journal-article" @default.
• W2108290804 hasAuthorship W2108290804A5011504486 @default.
• W2108290804 hasAuthorship W2108290804A5022758679 @default.
• W2108290804 hasAuthorship W2108290804A5035114536 @default.
• W2108290804 hasAuthorship W2108290804A5079413998 @default.
• W2108290804 hasConcept C126322002 @default.
• W2108290804 hasConcept C12722491 @default.
• W2108290804 hasConcept C134018914 @default.
• W2108290804 hasConcept C142724271 @default.
• W2108290804 hasConcept C150903083 @default.
• W2108290804 hasConcept C185592680 @default.
• W2108290804 hasConcept C196822366 @default.
• W2108290804 hasConcept C207001950 @default.
• W2108290804 hasConcept C2776637226 @default.
• W2108290804 hasConcept C2776914184 @default.
• W2108290804 hasConcept C2777622882 @default.
• W2108290804 hasConcept C2778722691 @default.
• W2108290804 hasConcept C2778904781 @default.
• W2108290804 hasConcept C2859252 @default.
• W2108290804 hasConcept C519581460 @default.
• W2108290804 hasConcept C71924100 @default.
• W2108290804 hasConcept C86803240 @default.
• W2108290804 hasConcept C98274493 @default.
• W2108290804 hasConceptScore W2108290804C126322002 @default.
• W2108290804 hasConceptScore W2108290804C12722491 @default.
• W2108290804 hasConceptScore W2108290804C134018914 @default.
• W2108290804 hasConceptScore W2108290804C142724271 @default.
• W2108290804 hasConceptScore W2108290804C150903083 @default.
• W2108290804 hasConceptScore W2108290804C185592680 @default.
• W2108290804 hasConceptScore W2108290804C196822366 @default.
• W2108290804 hasConceptScore W2108290804C207001950 @default.
• W2108290804 hasConceptScore W2108290804C2776637226 @default.
• W2108290804 hasConceptScore W2108290804C2776914184 @default.
• W2108290804 hasConceptScore W2108290804C2777622882 @default.
• W2108290804 hasConceptScore W2108290804C2778722691 @default.
• W2108290804 hasConceptScore W2108290804C2778904781 @default.
• W2108290804 hasConceptScore W2108290804C2859252 @default.
• W2108290804 hasConceptScore W2108290804C519581460 @default.
• W2108290804 hasConceptScore W2108290804C71924100 @default.
• W2108290804 hasConceptScore W2108290804C86803240 @default.
• W2108290804 hasConceptScore W2108290804C98274493 @default.

• next