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- W2108290846 abstract "FBD, a Chinese herbal formula, composed of Fu Ling [the sclerotium of the fungus of Poria cocos (Schw.) Wolf (Polyporaceae)], Bai Zhu [the rhizome of Atractylodes macrocephala Koidz.(Compositae)], and Danggui [the root of Angelica sinensis (Oliv.) Diels (Umbelliferae)], has been found beneficial in treating brain ischemia-reperfusion (I/R). In this work, oral pretreatment with supercritical CO2 extract (FBD-CO2, 37. 5 mg/kg) twice daily for 3.5 days, significantly attenuated brain infarction (p < 0.05), blocked neuron specific enolase (NSE) efflux (p < 0.05) in mice subjected to repetitive 10 min of common carotid artery occlusion following 24 h reperfusion, whether coupled with aqueous extract (FBD-H2O, 150 mg/kg) or not. Except atractylenolide I and pachymic acid, atractylenolide II, III, levistolid A, and ferulic acid isolated from FBD-CO2 alone protected neuron-like PC12 cells obviously and concentration-dependently against I/R-like insults (p < 0.05 ~ 0.01) induced by sodium dithionite (10 mM), monos..." @default.
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- W2108290846 date "2009-06-22" @default.
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- W2108290846 title "Neuroprotection by herbal formula FBD and its active compounds" @default.
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