FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108296045> ?p ?o ?g. }

• W2108296045 endingPage "671" @default.
• W2108296045 startingPage "664" @default.
• W2108296045 abstract "Products from the degradation of the branched-chain amino acids valine, leucine, and isoleucine contribute to the production of a number of important cellular metabolites, including branched-chain fatty acids, ATP and other energy production, cell-cell signaling for morphological development, and the synthesis of precursors for polyketide antibiotics. The first nonreversible reactions in the degradation of all three amino acids are catalyzed by the same branched-chain alpha-keto acid dehydrogenase (BCDH) complex. Actinomycetes are apparently unique among bacteria in that they contain two separate gene clusters, each of which encodes a BCDH enzyme complex. Here, we show that one of these clusters in Streptomyces coelicolor is regulated, at least in part, at the level of transcription by the product of the bkdR gene. The predicted product of this gene is a protein with similarity to a family of proteins that respond to leucine and serve to activate transcription of amino acid utilization operons. Unlike most other members of this class, however, the S. coelicolor bkdR gene product serves to repress transcription, suggesting that the branched-chain amino acids act as inducers rather than coactivators of transcription. BkdR likely responds to the presence of branched-chain amino acids. Its role in transcriptional regulation may be rationalized by the fact that transition from vegetative growth to aerial mycelium production, the first stage of morphological development in these complex bacteria, is coincident with extensive cellular lysis generating abundant amounts of protein that likely serve as the predominant source of carbon and nitrogen for metabolism. We suggest that bkdR plays a key role in the ability of Streptomyces species to sense nutrient availability and redirect metabolism for the utilization of branched-chain amino acids for energy, carbon, and perhaps even morphogen synthesis. A null mutant of bkdR is itself defective in morphogenesis and antibiotic production, suggesting that the role of the bkdR gene product may be more global than specific nutrient utilization." @default.
• W2108296045 created "2016-06-24" @default.
• W2108296045 creator A5001120663 @default.
• W2108296045 creator A5041559766 @default.
• W2108296045 creator A5047250037 @default.
• W2108296045 creator A5053455520 @default.
• W2108296045 creator A5087994374 @default.
• W2108296045 date "2005-01-15" @default.
• W2108296045 modified "2023-10-14" @default.
• W2108296045 title "The <i>bkdR</i> Gene of <i>Streptomyces coelicolor</i> Is Required for Morphogenesis and Antibiotic Production and Encodes a Transcriptional Regulator of a Branched-Chain Amino Acid Dehydrogenase Complex" @default.
• W2108296045 cites W1480622433 @default.
• W2108296045 cites W1699056345 @default.
• W2108296045 cites W1773725295 @default.
• W2108296045 cites W1909672973 @default.
• W2108296045 cites W1935374737 @default.
• W2108296045 cites W1973138933 @default.
• W2108296045 cites W1982658095 @default.
• W2108296045 cites W1990335821 @default.
• W2108296045 cites W1995995599 @default.
• W2108296045 cites W2023950913 @default.
• W2108296045 cites W2027211204 @default.
• W2108296045 cites W2037160383 @default.
• W2108296045 cites W2048323317 @default.
• W2108296045 cites W2067567259 @default.
• W2108296045 cites W2067609231 @default.
• W2108296045 cites W2078203842 @default.
• W2108296045 cites W2086432676 @default.
• W2108296045 cites W2096192450 @default.
• W2108296045 cites W2096419624 @default.
• W2108296045 cites W2108092248 @default.
• W2108296045 cites W2108603859 @default.
• W2108296045 cites W2119543534 @default.
• W2108296045 cites W2120602222 @default.
• W2108296045 cites W2134575886 @default.
• W2108296045 cites W2137421566 @default.
• W2108296045 cites W2151088332 @default.
• W2108296045 cites W2151976860 @default.
• W2108296045 cites W2155468175 @default.
• W2108296045 cites W2386558154 @default.
• W2108296045 cites W2414498782 @default.
• W2108296045 cites W243266443 @default.
• W2108296045 doi "https://doi.org/10.1128/jb.187.2.664-671.2005" @default.
• W2108296045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/543559" @default.
• W2108296045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15629937" @default.
• W2108296045 hasPublicationYear "2005" @default.
• W2108296045 type Work @default.
• W2108296045 sameAs 2108296045 @default.
• W2108296045 citedByCount "48" @default.
• W2108296045 countsByYear W21082960452012 @default.
• W2108296045 countsByYear W21082960452013 @default.
• W2108296045 countsByYear W21082960452014 @default.
• W2108296045 countsByYear W21082960452015 @default.
• W2108296045 countsByYear W21082960452016 @default.
• W2108296045 countsByYear W21082960452017 @default.
• W2108296045 countsByYear W21082960452018 @default.
• W2108296045 countsByYear W21082960452019 @default.
• W2108296045 countsByYear W21082960452020 @default.
• W2108296045 countsByYear W21082960452021 @default.
• W2108296045 countsByYear W21082960452022 @default.
• W2108296045 countsByYear W21082960452023 @default.
• W2108296045 crossrefType "journal-article" @default.
• W2108296045 hasAuthorship W2108296045A5001120663 @default.
• W2108296045 hasAuthorship W2108296045A5041559766 @default.
• W2108296045 hasAuthorship W2108296045A5047250037 @default.
• W2108296045 hasAuthorship W2108296045A5053455520 @default.
• W2108296045 hasAuthorship W2108296045A5087994374 @default.
• W2108296045 hasBestOaLocation W21082960451 @default.
• W2108296045 hasConcept C104317684 @default.
• W2108296045 hasConcept C143065580 @default.
• W2108296045 hasConcept C150194340 @default.
• W2108296045 hasConcept C165864922 @default.
• W2108296045 hasConcept C195286587 @default.
• W2108296045 hasConcept C203075996 @default.
• W2108296045 hasConcept C2776580952 @default.
• W2108296045 hasConcept C2776668381 @default.
• W2108296045 hasConcept C2777573094 @default.
• W2108296045 hasConcept C2779920670 @default.
• W2108296045 hasConcept C2780677274 @default.
• W2108296045 hasConcept C2780681812 @default.
• W2108296045 hasConcept C33498276 @default.
• W2108296045 hasConcept C515207424 @default.
• W2108296045 hasConcept C523546767 @default.
• W2108296045 hasConcept C54355233 @default.
• W2108296045 hasConcept C55493867 @default.
• W2108296045 hasConcept C86803240 @default.
• W2108296045 hasConceptScore W2108296045C104317684 @default.
• W2108296045 hasConceptScore W2108296045C143065580 @default.
• W2108296045 hasConceptScore W2108296045C150194340 @default.
• W2108296045 hasConceptScore W2108296045C165864922 @default.
• W2108296045 hasConceptScore W2108296045C195286587 @default.
• W2108296045 hasConceptScore W2108296045C203075996 @default.
• W2108296045 hasConceptScore W2108296045C2776580952 @default.
• W2108296045 hasConceptScore W2108296045C2776668381 @default.
• W2108296045 hasConceptScore W2108296045C2777573094 @default.
• W2108296045 hasConceptScore W2108296045C2779920670 @default.
• W2108296045 hasConceptScore W2108296045C2780677274 @default.
• W2108296045 hasConceptScore W2108296045C2780681812 @default.
• W2108296045 hasConceptScore W2108296045C33498276 @default.

• next