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• W2108304881 abstract "No AccessJournal of UrologyPEDIATRIC UROLOGY: Classic Article in Pediatric Urology1 Aug 2002Endocrine Screening in 32 Consecutive Patients with Hypospadias Axel Feyaerts, Maguelone G. Forest, Yves Morel, Pierre-Yves Mure, Nicolas Morel-Journel, Delphine Mallet, Marc Nicolino, Pierre Chatelain, Michel David, and Pierre Mouriquand Axel FeyaertsAxel Feyaerts More articles by this author , Maguelone G. ForestMaguelone G. Forest More articles by this author , Yves MorelYves Morel More articles by this author , Pierre-Yves MurePierre-Yves Mure More articles by this author , Nicolas Morel-JournelNicolas Morel-Journel More articles by this author , Delphine MalletDelphine Mallet More articles by this author , Marc NicolinoMarc Nicolino More articles by this author , Pierre ChatelainPierre Chatelain More articles by this author , Michel DavidMichel David More articles by this author , and Pierre MouriquandPierre Mouriquand More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64733-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Various endocrine studies performed in the hypospadias population show an unsatisfactory response to the human chorionic gonadotropin (HCG) test and abnormal androgen biosynthesis with possible enzyme defects. We evaluated the incidence of disorders in androgen production in boys with isolated hypospadias. Materials and Methods: A total of 32 consecutive children (46,XY) with hypospadias were prospectively enrolled in the study. Severity of the defect was assessed with a new classification based on the location of the division of the corpus spongiosum. Endocrine evaluation consisted of measuring luteinizing hormone, follicle-stimulating hormone, anti-müllerian hormone (AMH), testosterone, dihydrotestosterone, progesterone, 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone sulfate and Δ4-androstenedione. In all but 3 patients gonadal stimulation with 1,500 IU HCG every other day for 12 days was performed and steroid concentrations were reassessed after the test. An adrenocorticotropic hormone test was performed in 2 patients and molecular study of the androgen receptor was performed in 28. Results: An increase to 37.37 nmol./l. progesterone (normal 0.1 to 0.5) and 17α-hydroxyprogesterone to 25.48 nmol./l. (normal 1.18 ± 0.66) before HCG stimulation was noted in 1 patient. These abnormal results were not found after HCG stimulation but reappeared after the adrenocorticotropic hormone test. This result might be related to a partial mix of 17α-hydroxylase/17,20-lyase deficiency but no mutation was found after complete sequencing of gene CYP17. Of the 32 patients 4 had an insufficient response to HCG stimulation (testosterone less than 10 nmol./l.), including 1 with a low AMH level of 180 pmol./l. (normal 451 ± 198) and an increased dehydroepiandrosterone sulfate level of 1,995 nmol./l. (normal 59 ± 41) before HCG stimulation. Partial androgen insensitivity was suspected in 1 patient because he had a high testosterone response (29.96 nmol./l.) after HCG stimulation but no mutation of the gene of the androgen receptor was detected. Two patients with proximal hypospadias had isolated decreased AMH levels, which was evidence of Sertoli cell insufficiency. Conclusions: Although our series of 32 patients had several abnormal endocrine screenings, these results indicate no significant endocrine defects. References 1 : Plasma testosterone in male puberty. II. hCG stimulation test in boys with hypospadia. Acta Endocrinol (Copenh)1979; 90: 365. Google Scholar 2 : Endocrine studies in patients with advanced hypospadias. J Urol1984; 131: 310. Link, Google Scholar 3 : Pituitary and gonadal function in prepubertal boys with hypospadias. J Urol1984; 132: 595. Link, Google Scholar 4 : Gonadotropin and testosterone response in prepubertal boys with hypospadias. J Urol1986; 135: 539. Link, Google Scholar 5 : Testicular function in patients with hypospadias associated with enlarged prostatic utricule. Br J Urol1992; 69: 192. Google Scholar 6 : Plasma testosterone values in hypospadiacs. Andrologia1976; 8: 255. 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Google Scholar From the Departments of Pediatric Urology, Pediatric Endocrinology and INSERM U329, Biochimie Endocrinienne et Métabolique, Hôpital Debrousse, Hospices Civils de Lyon, Lyon, France© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byMoriya K, Mitsui T, Tanaka H, Nakamura M and Nonomura K (2010) Long-Term Outcome of Pituitary-Gonadal Axis and Gonadal Growth in Patients With Hypospadias at PubertyJournal of Urology, VOL. 184, NO. 4S, (1610-1614), Online publication date: 1-Oct-2010.LORENZO A, NGUYEN M, SOZUBIR S, HENKEMEYER M and BAKER L (2018) Dihydrotestosterone Induction of EphB2 Expression in the Female Genital Tubercle Mimics Male Pattern of Expression During EmbryogenesisJournal of Urology, VOL. 170, NO. 4 Part 2, (1618-1623), Online publication date: 1-Oct-2003. Volume 168Issue 2August 2002Page: 720-725 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.KeywordshypospadiasendocrinologyhormonestestosteroneMetricsAuthor Information Axel Feyaerts More articles by this author Maguelone G. Forest More articles by this author Yves Morel More articles by this author Pierre-Yves Mure More articles by this author Nicolas Morel-Journel More articles by this author Delphine Mallet More articles by this author Marc Nicolino More articles by this author Pierre Chatelain More articles by this author Michel David More articles by this author Pierre Mouriquand More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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