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- W2108308082 abstract "Accumulating evidence suggested that cyclophilin A (CyPA) can be regarded as a proinflammatory and proatherogenic molecule and played an important role in several stages of atherosclerosis. Recently, data from our laboratory demonstrated that elevated level of CyPA was associated with increased cardiac risk and maybe a marker of plaque instability [ [1] Yan J. Zang X. Chen R. et al. The clinical implications of increased cyclophilin A levels in patients with acute coronary syndromes. Clin Chim Acta. 2012 Apr 11; 413: 691-695 Crossref PubMed Scopus (25) Google Scholar ]. Furthermore, CyPA was atherogenic by initiating antiapoptotic and proapoptotic signaling pathway, suggesting CyPA as a target for atherosclerosis therapy [ [2] Wei Y. Jinchuan Y. Yi L. Jun W. Zhongqun W. Cuiping W. Antiapoptotic and proapoptotic signaling of cyclophilin A in endothelial cells. Inflammation. 2013 Jun; 36: 567-572 Crossref PubMed Scopus (24) Google Scholar ]. Although cyclosporin A (CsA), the immunosuppressive drug that inhibits CyPA, leads to a decreased risk of arteriosclerosis [ [3] Oryoji K. Kiyohara C. Horiuchi T. et al. Reduced carotid intima-media thickness in systemic lupus erythematosus patients treated with cyclosporine A. Mod Rheumatol. 2013 Mar 12; https://doi.org/10.1007/s10165-013-0832-0 Crossref Scopus (2) Google Scholar ], the effects of CsA on the risk of atherosclerosis are contradictory and not conclusive. Up to now the utility of gene silencing of CyPA by lentivirus vectors as a treatment for atherosclerosis diseases has not yet been reported. In this study, we constructed lentivirus-mediated gene transfer of CyPA using siRNA in reducing atherosclerosis lesions in ApoE −/− mice." @default.
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- W2108308082 date "2013-11-01" @default.
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- W2108308082 title "Regression of atherosclerotic plaques after lentivirus-mediated RNA interference of Cyclophilin A in ApoE−/− mice" @default.
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- W2108308082 doi "https://doi.org/10.1016/j.ijcard.2013.10.039" @default.
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