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• W2108322455 abstract "More than 30 missense mutations in the beta-cardiac myosin heavy chain gene have been shown to be responsible for familial hypertrophic cardiomyopathy. To clarify the effects of these point mutations on myosin motor function, we expressed wild-type and mutant human beta-cardiac myosin heavy chains in insect cells with human cardiac light chains. The wild-type myosin was well purified with similar enzymatic and motor activities to those of the naturally isolated V3 cardiac myosin. Arg249-->Gln and Arg453-->Cys mutations resulted in decreased actin translocating activity (61 and 23% of the wild-type, respectively) with decreased intrinsic ATPase activity. Arg403-->Gln mutation greatly decreased actin translocating activity (27% of wild type) with a 3.3-fold increased dissociation constant for actin, while intrinsic ATPase activity was unchanged. Val606-->Met mutation only mildly affected the actin translocating activity as well as ATPase activity of myosin. The degree of deterioration by each mutation was closely correlated with the prognosis of the affected kindreds, indicating that myosin dysfunction caused by the point mutations is responsible for the pathogenesis of the disease. Structure/function relationship of myosin is discussed." @default.
• W2108322455 created "2016-06-24" @default.
• W2108322455 creator A5062493641 @default.
• W2108322455 creator A5078739904 @default.
• W2108322455 date "1996-12-15" @default.
• W2108322455 modified "2023-09-25" @default.
• W2108322455 title "Functional analysis of the mutations in the human cardiac beta-myosin that are responsible for familial hypertrophic cardiomyopathy. Implication for the clinical outcome." @default.
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• W2108322455 doi "https://doi.org/10.1172/jci119115" @default.
• W2108322455 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/507754" @default.
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• W2108322455 hasPublicationYear "1996" @default.
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