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• W2108328346 abstract "The fundamental role of the major histocompatibility complex (MHC) in immune recognition has led to a general consensus that the characteristically high levels of functional polymorphism at MHC genes is maintained by balancing selection operating through host-parasite coevolution. However, the actual mechanism by which selection operates is unclear. Two hypotheses have been proposed: overdominance (or heterozygote superiority) and negative frequency-dependent selection. Evidence for these hypotheses was evaluated by examining MHC-parasite relationships in an island population of water voles (Arvicola terrestris). Generalized linear mixed models were used to examine whether individual variation at an MHC class II DRB locus explained variation in the individual burdens of five different parasites. MHC genotype explained a significant amount of variation in the burden of gamasid mites, fleas (Megabothris walkeri) and nymphs of sheep ticks (Ixodes ricinus). Additionally, MHC heterozygotes were simultaneously co-infected by fewer parasite types than homozygotes. In each case where an MHC-dependent effect on parasite burden was resolved, the heterozygote genotype was associated with fewer parasites, and the heterozygote outperformed each homozygote in two of three cases, suggesting an overall superiority against parasitism for MHC heterozygote genotypes. This is the first demonstration of MHC heterozygote superiority against multiple parasites in a natural population, a mechanism that could help maintain high levels of functional MHC genetic diversity in natural populations." @default.
• W2108328346 created "2016-06-24" @default.
• W2108328346 creator A5005688877 @default.
• W2108328346 creator A5009834561 @default.
• W2108328346 creator A5022065765 @default.
• W2108328346 date "2008-12-09" @default.
• W2108328346 modified "2023-10-16" @default.
• W2108328346 title "Major histocompatibility complex (MHC) heterozygote superiority to natural multi-parasite infections in the water vole ( <i>Arvicola terrestris</i> )" @default.
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• W2108328346 doi "https://doi.org/10.1098/rspb.2008.1525" @default.
• W2108328346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2679068" @default.
• W2108328346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19129114" @default.
• W2108328346 hasPublicationYear "2008" @default.
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