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- W2108332536 endingPage "5091" @default.
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- W2108332536 abstract "Alphaviruses are enveloped icosahedral viruses that mature by budding at the plasma membrane. According to a prevailing model maturation is driven by binding of membrane protein spikes to a preformed nucleocapsid (NC). The T = 4 geometry of the membrane is thought to be imposed by the NC through one-to-one interactions between spike protomers and capsid proteins (CPs). This model is challenged here by a Semliki Forest virus capsid gene mutant. Its CPs cannot assemble into NCs, or its intermediate structures, due to defective CP-CP interactions. Nevertheless, it can use its horizontal spike-spike interactions on membrane surface and vertical spike-CP interactions to make a particle with correct geometry and protein stoichiometry. Thus, our results highlight the direct role of membrane proteins in organizing the icosahedral conformation of alphaviruses." @default.
- W2108332536 created "2016-06-24" @default.
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- W2108332536 date "2000-10-02" @default.
- W2108332536 modified "2023-10-01" @default.
- W2108332536 title "Membrane proteins organize a symmetrical virus" @default.
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- W2108332536 doi "https://doi.org/10.1093/emboj/19.19.5081" @default.
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