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- W2108335123 abstract "Tartary buckwheat (Fagopyrum tataricum) is a healthy and nutritionally important food item. In this study, we investigated the hepatoprotective effects of 75% ethanol extracts from tartary buckwheat (EEB) against ethanol- and carbon tetrachloride (CCl4)-induced liver damage. EEB were administered to C57BL/6 mice (ethanol induction) and Sprague-Dawley (SD) rats (CCl4 induction) for 4 and 8 consecutive weeks, respectively. The major active compounds, rutin and quercetin, were also administered to ethanol- and CCl4-induced animals. EEB inhibited increase in serum aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) levels in the ethanol- and CCl4-induced animals; similar effects were found after rutin and quercetin administration. Moreover, EEB elevated the antioxidant enzyme activities, including those of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and superoxide dismutase (SOD), and inhibited the levels of hepatic inflammation in the ethanol- and CCl4-treated animals. This study suggests that EEB exerts hepatoprotection via promoting anti-oxidative and anti-inflammatory properties against oxidative liver damage." @default.
- W2108335123 created "2016-06-24" @default.
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- W2108335123 date "2013-01-01" @default.
- W2108335123 modified "2023-10-18" @default.
- W2108335123 title "Rutin and quercetin, bioactive compounds from tartary buckwheat, prevent liver inflammatory injury" @default.
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- W2108335123 doi "https://doi.org/10.1039/c3fo30389f" @default.
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