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• W2108352017 abstract "The purpose of this study was to replicate findings from an earlier pilot study in which we found a dose-related effect of the opioid antagonist naloxone on tic behavior in patients with Tourette's syndrome (TS). Fifteen subjects with TS were challenged with randomized doses (30 and 300 μg/kg) of naloxone at 3-day intervals. Videotaped recordings of tic behavior were counted in a “blind” fashion. We found that naloxone had opposite effects on tics at different dosages. The low dose caused a significant decrease in tics, whereas the high dose caused a significant increase in tics. Therefore, activity at opioid receptors appears to influence the expression of TS, and the difference in response to naloxone in TS subjects may be based on a dose-response effect." @default.
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• W2108352017 date "2000-11-01" @default.
• W2108352017 modified "2023-10-14" @default.
• W2108352017 title "Patterns of response to acute naloxone infusion in Tourette's syndrome" @default.
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• W2108352017 doi "https://doi.org/10.1002/1531-8257(200011)15:6<1252::aid-mds1030>3.0.co;2-i" @default.
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