Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108352507> ?p ?o ?g. }
- W2108352507 endingPage "4879" @default.
- W2108352507 startingPage "4867" @default.
- W2108352507 abstract "Thymic stromal lymphopoietin (TSLP) recently has emerged as a key cytokine in the development of type 2 immune responses. Although traditionally associated with allergic inflammation, type 2 responses are also recognized to contribute to the pathogenesis of tissue fibrosis. However, the role of TSLP in the development of non-allergen-driven diseases, characterized by profibrotic type 2 immune phenotypes and excessive fibroblast activation, remains underexplored. Fibroblasts represent the key effector cells responsible for extracellular matrix production but additionally play important immunoregulatory roles, including choreographing immune cell recruitment through chemokine regulation. The aim of this study was to examine whether TSLP may be involved in the pathogenesis of a proto-typical fibrotic disease, idiopathic pulmonary fibrosis (IPF). We combined the immunohistochemical analysis of human IPF biopsy material with signaling studies by using cultured primary human lung fibroblasts and report for the first time, to our knowledge, that TSLP and its receptor (TSLPR) are highly upregulated in IPF. We further show that lung fibroblasts represent both a novel cellular source and target of TSLP and that TSLP induces fibroblast CCL2 release (via STAT3) and subsequent monocyte chemotaxis. These studies extend our understanding of TSLP as a master regulator of type 2 immune responses beyond that of allergic inflammatory conditions and suggest a novel role for TSLP in the context of chronic fibrotic lung disease." @default.
- W2108352507 created "2016-06-24" @default.
- W2108352507 creator A5015939569 @default.
- W2108352507 creator A5058325633 @default.
- W2108352507 creator A5065024263 @default.
- W2108352507 creator A5069722362 @default.
- W2108352507 creator A5075891901 @default.
- W2108352507 creator A5077791152 @default.
- W2108352507 creator A5090076776 @default.
- W2108352507 date "2013-09-30" @default.
- W2108352507 modified "2023-10-15" @default.
- W2108352507 title "Evidence for a Functional Thymic Stromal Lymphopoietin Signaling Axis in Fibrotic Lung Disease" @default.
- W2108352507 cites W1558665965 @default.
- W2108352507 cites W1602068304 @default.
- W2108352507 cites W1625157530 @default.
- W2108352507 cites W1687290736 @default.
- W2108352507 cites W1823764983 @default.
- W2108352507 cites W1834059013 @default.
- W2108352507 cites W1944675847 @default.
- W2108352507 cites W1950204667 @default.
- W2108352507 cites W1973864734 @default.
- W2108352507 cites W1979026253 @default.
- W2108352507 cites W1981420729 @default.
- W2108352507 cites W1988896491 @default.
- W2108352507 cites W1991656827 @default.
- W2108352507 cites W1994839187 @default.
- W2108352507 cites W2006318162 @default.
- W2108352507 cites W2006514214 @default.
- W2108352507 cites W2007157616 @default.
- W2108352507 cites W2014884192 @default.
- W2108352507 cites W2019628625 @default.
- W2108352507 cites W2025502983 @default.
- W2108352507 cites W2026813843 @default.
- W2108352507 cites W2026995229 @default.
- W2108352507 cites W2027180323 @default.
- W2108352507 cites W2027314854 @default.
- W2108352507 cites W2034338127 @default.
- W2108352507 cites W2037174767 @default.
- W2108352507 cites W2038489376 @default.
- W2108352507 cites W2046136375 @default.
- W2108352507 cites W2051195214 @default.
- W2108352507 cites W2055861133 @default.
- W2108352507 cites W2057450814 @default.
- W2108352507 cites W2058582950 @default.
- W2108352507 cites W2058894435 @default.
- W2108352507 cites W2064087919 @default.
- W2108352507 cites W2068870295 @default.
- W2108352507 cites W2071251698 @default.
- W2108352507 cites W2073381161 @default.
- W2108352507 cites W2076527353 @default.
- W2108352507 cites W2077888205 @default.
- W2108352507 cites W2083410475 @default.
- W2108352507 cites W2087842571 @default.
- W2108352507 cites W2089709635 @default.
- W2108352507 cites W2091886117 @default.
- W2108352507 cites W2092157690 @default.
- W2108352507 cites W2093907019 @default.
- W2108352507 cites W2099048640 @default.
- W2108352507 cites W2103685679 @default.
- W2108352507 cites W2103874288 @default.
- W2108352507 cites W2105859711 @default.
- W2108352507 cites W2105927222 @default.
- W2108352507 cites W2106964870 @default.
- W2108352507 cites W2109755061 @default.
- W2108352507 cites W2109909774 @default.
- W2108352507 cites W2111672303 @default.
- W2108352507 cites W2111709938 @default.
- W2108352507 cites W2114792426 @default.
- W2108352507 cites W2119414259 @default.
- W2108352507 cites W2128190180 @default.
- W2108352507 cites W2128464705 @default.
- W2108352507 cites W2131268464 @default.
- W2108352507 cites W2135790224 @default.
- W2108352507 cites W2137465231 @default.
- W2108352507 cites W2137561439 @default.
- W2108352507 cites W2139169478 @default.
- W2108352507 cites W2149336558 @default.
- W2108352507 cites W2152108405 @default.
- W2108352507 cites W2154562589 @default.
- W2108352507 cites W2156665195 @default.
- W2108352507 cites W2156936329 @default.
- W2108352507 cites W2158500407 @default.
- W2108352507 cites W2158634191 @default.
- W2108352507 cites W2160161426 @default.
- W2108352507 cites W2162661249 @default.
- W2108352507 cites W2164998164 @default.
- W2108352507 cites W2167645193 @default.
- W2108352507 cites W2170948066 @default.
- W2108352507 cites W2171225939 @default.
- W2108352507 cites W2789682581 @default.
- W2108352507 cites W4234293350 @default.
- W2108352507 doi "https://doi.org/10.4049/jimmunol.1300588" @default.
- W2108352507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3836180" @default.
- W2108352507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24081992" @default.
- W2108352507 hasPublicationYear "2013" @default.
- W2108352507 type Work @default.
- W2108352507 sameAs 2108352507 @default.
- W2108352507 citedByCount "51" @default.