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• W2108358210 abstract "ABSTRACT Antibody and cytotoxic T-lymphocyte (CTL) responses have critical roles in eliminating many viral infections. In addition to stimulation of the T-cell receptor, T cells require costimulatory signals to respond optimally. We evaluated the role of B7 costimulatory molecules (B7-1 and B7-2) in the immune response to viral infection using vesicular stomatitis virus (VSV) and mice lacking either B7-1 or B7-2 or both molecules. Mice lacking both B7-1 and B7-2 had essentially no anti-VSV immunoglobulin G1 (IgG1) response, decreased IgG2a responses, and normal IgM responses, while mice lacking either B7-1 or B7-2 had unaltered anti-VSV antibody responses compared to wild-type mice. Depletion of CD4 + cells further reduced the IgG2a response in mice lacking both B7 molecules, suggesting that CD4 − cells may supply help for IgG2a in the absence of B7 costimulation. The absence of both B7 molecules profoundly reduced generation of both primary and secondary VSV-specific class I major histocompatibility complex (MHC)-restricted CTL, whereas VSV-specific CTL responses in mice lacking either B7-1 or B7-2 were similar to those of wild-type animals. Class I MHC-restricted CTL in wild-type mice were not dependent on CD4 + cells, suggesting that the failure of CTL in the absence of B7s is due to a lack of B7 costimulation directly to the CD8 + CTL. These data demonstrate that B7-1 and B7-2 have critical, overlapping functions in the antibody and CTL responses to this viral infection." @default.
• W2108358210 created "2016-06-24" @default.
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• W2108358210 date "2000-01-01" @default.
• W2108358210 modified "2023-10-13" @default.
• W2108358210 title "B7 Costimulation Is Critical for Antibody Class Switching and CD8 ⁺ Cytotoxic T-Lymphocyte Generation in the Host Response to Vesicular Stomatitis Virus" @default.
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• W2108358210 doi "https://doi.org/10.1128/jvi.74.1.203-208.2000" @default.
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