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• W2108362702 abstract "<b>Objective:</b> To assess the changing profile of infective endocarditis in patients with congenital heart disease. <b>Methods:</b> All cases diagnosed from 1966 to 2001 (revised Duke criteria) were retrospectively reviewed and categorised in periods I (< 1990) and II (⩾ 1990). <b>Results:</b> 153 episodes occurred, 81 in period I and 72 in period II. Mean age of affected patients was higher in period II. Non-operated ventricular septal defect, Rastelli correction and palliated cyanotic heart disease increased. Infective endocarditis in corrective surgery changed to patients with prosthetic material. Post-surgical cases decreased. Dental problems were the leading cause (period I 20% <i>v</i> II 33% of cases) with a large variety of pathological organisms (multiple species of <i>Streptococcus</i>). Cutaneous causative infections increased (5% to 17%) with different species of <i>Staphylococcus</i>. Negative blood cultures lessened (20% to 7%, p = 0.03). Streptococci were the most common causative organisms in both periods. Severe heart failure and cardiac complications lessened (20% to 4% and 31% to 18% during periods I and II, respectively). Early surgery was more frequent in period II (32% <i>v</i> 18.5%, p = 0.02). One- and 10-year survival was 91% <i>v</i> 97% in period I and 89% <i>v</i> 97% in period II, respectively (NS). <b>Conclusion:</b> Current targets include complex cyanotic disease, congenital heart disease corrected with prosthetic material and small ventricular septal defect. Postoperative cases lessened; dental and cutaneous causes increased. Survival was unchanged. Prophylactic measures targeted at dental and cutaneous sources should be emphasised." @default.
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• W2108362702 date "2006-05-15" @default.
• W2108362702 modified "2023-09-27" @default.
• W2108362702 title "Current patterns of infective endocarditis in congenital heart disease" @default.
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• W2108362702 doi "https://doi.org/10.1136/hrt.2005.085332" @default.
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