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- W2108365763 abstract "Toxoplasma gondii is an important zoonotic parasite with a worldwide distribution. It infects about one-third of the world's population, causing serious illness in immunosuppressed individuals, fetuses, and infants. Toxoplasma gondii biology within the host cell includes several important phases: (1) active invasion and establishment of a nonfusogenic parasitophorous vacuole in the host cell, (2) extensive modification of the parasitophorous vacuolar membrane for nutrient acquisition, (3) intracellular proliferation by endodyogeny, (4) egress and invasion of new host cells, and (5) stage conversion from tachyzoite to bradyzoite and establishment of chronic infection. During these processes, T. gondii regulates the host cell by modulating morphological, physiological, immunological, genetic, and cellular biological aspects of the host cell. Overall, the infection/development predispositions of T. gondii–host cell interactions overtakes the infection resistance aspects. Upon invasion and development, host cells are modulated to keep a delicate balance between facilitating and eliminating the infection." @default.
- W2108365763 created "2016-06-24" @default.
- W2108365763 creator A5031300564 @default.
- W2108365763 creator A5032482121 @default.
- W2108365763 creator A5091474005 @default.
- W2108365763 date "2011-08-01" @default.
- W2108365763 modified "2023-09-25" @default.
- W2108365763 title "A Review: Competence, Compromise, and Concomitance—Reaction of the Host Cell To Toxoplasma gondii Infection and Development" @default.
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- W2108365763 doi "https://doi.org/10.1645/ge-2712.1" @default.
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