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• W2108367459 abstract "Cell cycle regulatory molecules are implicated in cardiomyocyte hypertrophy. We have investigated protein expression of cyclins A, D1–3, and E and cyclin-dependent kinases (CDKs) 2, 4, 5, and 6 in left ventricular (LV) tissues during the development of LV hypertrophy in rats following aortic constriction (AC). Compared with their expression in sham-operated controls (SH), expression of cyclins D2 and D3 and of CDK4 and CDK6 increased significantly from day 3 to day 21 after AC concomitant with increased LV mass. However, no significant difference was observed for CDK2 or CDK5. Cyclins A, D1, and E were undetectable. In vitro kinase activities of CDK4 and CDK6 increased ∼70% from day 7 to day 14 in AC myocytes compared with SH myocytes ( P< 0.03). Fluorescence-activated cell sorter analysis revealed a G 0 /G 1 to G 2 /M phase progression in AC myocyte nuclei (22.0 ± 1.1% in G 2 /M) by day 7 postoperation compared with progression in SH myocyte nuclei (14.0 ± 0.8% in G 2 /M; P < 0.01). Thus an upregulation of certain cell cycle regulators is associated with cardiomyocyte hypertrophy." @default.
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• W2108367459 date "1998-09-01" @default.
• W2108367459 modified "2023-10-17" @default.
• W2108367459 title "Role of G₁phase cyclins and cyclin-dependent kinases during cardiomyocyte hypertrophic growth in rats" @default.
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• W2108367459 doi "https://doi.org/10.1152/ajpheart.1998.275.3.h814" @default.
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