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- W2108368185 abstract "This brief overview presents evidence to suggest that information storage, in part, may be based on synapse connectivity changes mediated by a replay of neurodevelopmental events. These considerations are based on studies which have monitored change in neural cell adhesion molecule (NCAM) sialylation state during acquisition and consolidation of a passive avoidance response in the adult rat. The synapse-specific isoform of NCAM, NCAM180 is demonstrated to increase sialylation state in the hippocampus between 12-24 h after training and to produce a novel sialylated form of 210 kDa. Interventive studies with specific antibodies showed NCAM to play a specific role at 6-8 h after training, the amnestic effect of which does not become apparent until the process of NCAM sialylation is complete." @default.
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- W2108368185 date "1992-01-01" @default.
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- W2108368185 title "Neurodevelopmental events underlying information acquisition and storage" @default.
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- W2108368185 doi "https://doi.org/10.1088/0954-898x_3_1_010" @default.
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