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- W2108371618 abstract "Spatial and temporal dissection of the genomic changes occurring during the evolution of human non–small cell lung cancer (NSCLC) may help elucidate the basis for its dismal prognosis. We sequenced 25 spatially distinct regions from seven operable NSCLCs and found evidence of branched evolution, with driver mutations arising before and after subclonal diversification. There was pronounced intratumor heterogeneity in copy number alterations, translocations, and mutations associated with APOBEC cytidine deaminase activity. Despite maintained carcinogen exposure, tumors from smokers showed a relative decrease in smoking-related mutations over time, accompanied by an increase in APOBEC-associated mutations. In tumors from former smokers, genome-doubling occurred within a smoking-signature context before subclonal diversification, which suggested that a long period of tumor latency had preceded clinical detection. The regionally separated driver mutations, coupled with the relentless and heterogeneous nature of the genome instability processes, are likely to confound treatment success in NSCLC." @default.
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- W2108371618 date "2014-10-10" @default.
- W2108371618 modified "2023-10-18" @default.
- W2108371618 title "Spatial and temporal diversity in genomic instability processes defines lung cancer evolution" @default.
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- W2108371618 cites W1987908519 @default.
- W2108371618 cites W2000905326 @default.
- W2108371618 cites W2003665515 @default.
- W2108371618 cites W2006288875 @default.
- W2108371618 cites W2011484895 @default.
- W2108371618 cites W2011728187 @default.
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- W2108371618 cites W2016661249 @default.
- W2108371618 cites W2025183726 @default.
- W2108371618 cites W2041937775 @default.
- W2108371618 cites W2041993682 @default.
- W2108371618 cites W2042386784 @default.
- W2108371618 cites W2045058134 @default.
- W2108371618 cites W2051676630 @default.
- W2108371618 cites W2067708830 @default.
- W2108371618 cites W2070841378 @default.
- W2108371618 cites W2075836790 @default.
- W2108371618 cites W2087464200 @default.
- W2108371618 cites W2087588809 @default.
- W2108371618 cites W2089750734 @default.
- W2108371618 cites W2093144236 @default.
- W2108371618 cites W2099441054 @default.
- W2108371618 cites W2103441770 @default.
- W2108371618 cites W2104153021 @default.
- W2108371618 cites W2104195581 @default.
- W2108371618 cites W2104224322 @default.
- W2108371618 cites W2105660237 @default.
- W2108371618 cites W2108234281 @default.
- W2108371618 cites W2109991075 @default.
- W2108371618 cites W2110171180 @default.
- W2108371618 cites W2114031931 @default.
- W2108371618 cites W2115494288 @default.
- W2108371618 cites W2115919763 @default.
- W2108371618 cites W2131876608 @default.
- W2108371618 cites W2132632499 @default.
- W2108371618 cites W2133568159 @default.
- W2108371618 cites W2136145671 @default.
- W2108371618 cites W2137220794 @default.
- W2108371618 cites W2138603354 @default.
- W2108371618 cites W2139216037 @default.
- W2108371618 cites W2144892629 @default.
- W2108371618 cites W2150575159 @default.
- W2108371618 cites W2152061559 @default.