FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108375881> ?p ?o ?g. }

• W2108375881 abstract "Abstract Background Vpx is a virion-associated protein encoded by SIV SM , a lentivirus endemic to the West African sooty mangabey ( Cercocebus atys ). HIV-2 and SIV MAC , zoonoses resulting from SIV SM transmission to humans or Asian rhesus macaques ( Macaca mulatta ), also encode Vpx. In myeloid cells, Vpx promotes reverse transcription and transduction by these viruses. This activity correlates with Vpx binding to DCAF1 (VPRBP) and association with the DDB1/RBX1/CUL4A E3 ubiquitin ligase complex. When delivered experimentally to myeloid cells using VSV G-pseudotyped virus-like particles (VLPs), Vpx promotes reverse transcription of retroviruses that do not normally encode Vpx. Results Here we show that Vpx has the extraordinary ability to completely rescue HIV-1 transduction of human monocyte-derived dendritic cells (MDDCs) from the potent antiviral state established by prior treatment with exogenous type 1 interferon (IFN). The magnitude of rescue was up to 1,000-fold, depending on the blood donor, and was also observed after induction of endogenous IFN and IFN-stimulated genes (ISGs) by LPS, poly(I:C), or poly(dA:dT). The effect was relatively specific in that Vpx-associated suppression of soluble IFN-β production, of mRNA levels for ISGs, or of cell surface markers for MDDC differentiation, was not detected. Vpx did not rescue HIV-2 or SIV MAC transduction from the antiviral state, even in the presence of SIV MAC or HIV-2 VLPs bearing additional Vpx, or in the presence of HIV-1 VLPs bearing all accessory genes. In contrast to the effect of Vpx on transduction of untreated MDDCs, HIV-1 rescue from the antiviral state was not dependent upon Vpx interaction with DCAF1 or on the presence of DCAF1 within the MDDC target cells. Additionally, although Vpx increased the level of HIV-1 reverse transcripts in MDDCs to the same extent whether or not MDDCs were treated with IFN or LPS, Vpx rescued a block specific to the antiviral state that occurred after HIV-1 cDNA penetrated the nucleus. Conclusion Vpx provides a tool for the characterization of a potent, new HIV-1 restriction activity, which acts in the nucleus of type 1 IFN-treated dendritic cells." @default.
• W2108375881 created "2016-06-24" @default.
• W2108375881 creator A5007161976 @default.
• W2108375881 creator A5081790590 @default.
• W2108375881 creator A5086001897 @default.
• W2108375881 date "2011-06-22" @default.
• W2108375881 modified "2023-10-16" @default.
• W2108375881 title "Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon" @default.
• W2108375881 cites W1494346716 @default.
• W2108375881 cites W1517131856 @default.
• W2108375881 cites W1557691749 @default.
• W2108375881 cites W1577222354 @default.
• W2108375881 cites W1661544713 @default.
• W2108375881 cites W1714042500 @default.
• W2108375881 cites W1844569659 @default.
• W2108375881 cites W1851544526 @default.
• W2108375881 cites W1908410208 @default.
• W2108375881 cites W1963855922 @default.
• W2108375881 cites W1965565827 @default.
• W2108375881 cites W1978560543 @default.
• W2108375881 cites W1991069890 @default.
• W2108375881 cites W1991686444 @default.
• W2108375881 cites W1993897877 @default.
• W2108375881 cites W1998397915 @default.
• W2108375881 cites W2001243226 @default.
• W2108375881 cites W2001375348 @default.
• W2108375881 cites W2001430278 @default.
• W2108375881 cites W2002980277 @default.
• W2108375881 cites W2006699168 @default.
• W2108375881 cites W2010458160 @default.
• W2108375881 cites W2010577903 @default.
• W2108375881 cites W2010840723 @default.
• W2108375881 cites W2011847596 @default.
• W2108375881 cites W2017116608 @default.
• W2108375881 cites W2019039109 @default.
• W2108375881 cites W2021067210 @default.
• W2108375881 cites W2026218505 @default.
• W2108375881 cites W2029884547 @default.
• W2108375881 cites W2029930485 @default.
• W2108375881 cites W2031295164 @default.
• W2108375881 cites W2031875199 @default.
• W2108375881 cites W2032539461 @default.
• W2108375881 cites W2033417059 @default.
• W2108375881 cites W2033467615 @default.
• W2108375881 cites W2033892196 @default.
• W2108375881 cites W2040589516 @default.
• W2108375881 cites W2042486230 @default.
• W2108375881 cites W2047452261 @default.
• W2108375881 cites W2049115723 @default.
• W2108375881 cites W2055050805 @default.
• W2108375881 cites W2057040546 @default.
• W2108375881 cites W2058902393 @default.
• W2108375881 cites W2060371587 @default.
• W2108375881 cites W2062254683 @default.
• W2108375881 cites W2063465748 @default.
• W2108375881 cites W2065470506 @default.
• W2108375881 cites W2068349374 @default.
• W2108375881 cites W2072901265 @default.
• W2108375881 cites W2075399607 @default.
• W2108375881 cites W2078489697 @default.
• W2108375881 cites W2086636233 @default.
• W2108375881 cites W2093579074 @default.
• W2108375881 cites W2094347764 @default.
• W2108375881 cites W2095364297 @default.
• W2108375881 cites W2098188064 @default.
• W2108375881 cites W2100145928 @default.
• W2108375881 cites W2100892474 @default.
• W2108375881 cites W2110609746 @default.
• W2108375881 cites W2111949375 @default.
• W2108375881 cites W2112112221 @default.
• W2108375881 cites W2112156721 @default.
• W2108375881 cites W2114216755 @default.
• W2108375881 cites W2115187431 @default.
• W2108375881 cites W2115657133 @default.
• W2108375881 cites W2120932519 @default.
• W2108375881 cites W2122123961 @default.
• W2108375881 cites W2122266844 @default.
• W2108375881 cites W2123913956 @default.
• W2108375881 cites W2125299662 @default.
• W2108375881 cites W2125393581 @default.
• W2108375881 cites W2127310510 @default.
• W2108375881 cites W2129784359 @default.
• W2108375881 cites W2132333091 @default.
• W2108375881 cites W2135830947 @default.
• W2108375881 cites W2136855305 @default.
• W2108375881 cites W2138933731 @default.
• W2108375881 cites W2140226886 @default.
• W2108375881 cites W2146187278 @default.
• W2108375881 cites W2147727360 @default.
• W2108375881 cites W2149401677 @default.
• W2108375881 cites W2152550969 @default.
• W2108375881 cites W2159006922 @default.
• W2108375881 cites W2159611842 @default.
• W2108375881 cites W2164223256 @default.
• W2108375881 cites W2168606329 @default.
• W2108375881 cites W2330865564 @default.
• W2108375881 cites W4239379492 @default.
• W2108375881 doi "https://doi.org/10.1186/1742-4690-8-49" @default.
• W2108375881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3130655" @default.
• W2108375881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21696578" @default.

• next