FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108377856> ?p ?o ?g. }

• W2108377856 endingPage "1501" @default.
• W2108377856 startingPage "1496" @default.
• W2108377856 abstract "Though diabetes is a disease with vascular complications, little is known about its effects on the blood-brain barrier or the blood-cerebrospinal fluid barrier (BCSFB). The BCSFB is situated at choroid plexuses located in the lateral, third, and fourth ventricles. Choroid plexuses are the primary site of cerebrospinal fluid (CSF) production and express numerous ion transporters. Previous studies have shown a perturbation of ion transport in the periphery and brain during diabetes. In this study, we investigated the effect of diabetes on ion transporters in the choroid plexuses of streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in male Sprague-Dawley rats by intraperitoneal injection of STZ (60 mg/kg in citrate buffer, confirmed by glucose analysis: 601 +/- 22 mg/dl diabetic rats, 181 +/- 46 mg/dl age-matched controls); and at 28 days, rats were killed, choroid plexuses harvested, and protein extracted. Western blot analyses were carried out using antibodies for ion transporters, including Na(+)-K(+)-2Cl(-) cotransporter and the Na(+)-K(+)-ATPase alpha1-subunit. The efflux of the K(+) analog (86)Rb(+) from choroid plexus was also studied. Diabetic rats showed an increase in expression of the Na(+)-K(+)-2Cl(-) cotransporter and the Na(+)-K(+)-ATPase alpha1-subunit, as compared with age-matched controls, a decrease in Na(+)-H(+) exchanger expression, and no change in Na(+)-K(+)-ATPase beta1- or beta2-subunit. The net effect of these changes was a 66% increase in (86)Rb(+) efflux from diabetic choroid plexus compared with controls. These changes in expression may affect choroid plexus ion balance and thus significantly affect CSF production in diabetic rats." @default.
• W2108377856 created "2016-06-24" @default.
• W2108377856 creator A5005477757 @default.
• W2108377856 creator A5008539103 @default.
• W2108377856 creator A5009238442 @default.
• W2108377856 creator A5038895323 @default.
• W2108377856 creator A5085069824 @default.
• W2108377856 date "2003-06-01" @default.
• W2108377856 modified "2023-09-25" @default.
• W2108377856 title "Differential Effects of Diabetes on Rat Choroid Plexus Ion Transporter Expression" @default.
• W2108377856 cites W1562290896 @default.
• W2108377856 cites W1566030776 @default.
• W2108377856 cites W1580552411 @default.
• W2108377856 cites W1594357708 @default.
• W2108377856 cites W165193783 @default.
• W2108377856 cites W1835792299 @default.
• W2108377856 cites W1965069515 @default.
• W2108377856 cites W1966012343 @default.
• W2108377856 cites W1969947674 @default.
• W2108377856 cites W1972942799 @default.
• W2108377856 cites W1974425528 @default.
• W2108377856 cites W1977861172 @default.
• W2108377856 cites W1982221258 @default.
• W2108377856 cites W1986030497 @default.
• W2108377856 cites W1988885884 @default.
• W2108377856 cites W1989145132 @default.
• W2108377856 cites W1989396651 @default.
• W2108377856 cites W1997765540 @default.
• W2108377856 cites W1999633001 @default.
• W2108377856 cites W2009477502 @default.
• W2108377856 cites W2013633841 @default.
• W2108377856 cites W2019483792 @default.
• W2108377856 cites W2021759517 @default.
• W2108377856 cites W2041483033 @default.
• W2108377856 cites W2047913307 @default.
• W2108377856 cites W2050594546 @default.
• W2108377856 cites W2051108627 @default.
• W2108377856 cites W2056085368 @default.
• W2108377856 cites W2058256484 @default.
• W2108377856 cites W2082739856 @default.
• W2108377856 cites W2093671086 @default.
• W2108377856 cites W2102931413 @default.
• W2108377856 cites W2114787445 @default.
• W2108377856 cites W2152899125 @default.
• W2108377856 cites W2164062635 @default.
• W2108377856 cites W2207975538 @default.
• W2108377856 cites W2230118829 @default.
• W2108377856 cites W2281807099 @default.
• W2108377856 cites W2287084658 @default.
• W2108377856 cites W2339284332 @default.
• W2108377856 cites W2339468052 @default.
• W2108377856 cites W2396234209 @default.
• W2108377856 cites W2405398885 @default.
• W2108377856 cites W2414967874 @default.
• W2108377856 cites W2472696710 @default.
• W2108377856 cites W4232726197 @default.
• W2108377856 cites W4248743568 @default.
• W2108377856 cites W2062805556 @default.
• W2108377856 doi "https://doi.org/10.2337/diabetes.52.6.1496" @default.
• W2108377856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12765962" @default.
• W2108377856 hasPublicationYear "2003" @default.
• W2108377856 type Work @default.
• W2108377856 sameAs 2108377856 @default.
• W2108377856 citedByCount "25" @default.
• W2108377856 countsByYear W21083778562012 @default.
• W2108377856 countsByYear W21083778562013 @default.
• W2108377856 countsByYear W21083778562014 @default.
• W2108377856 countsByYear W21083778562016 @default.
• W2108377856 countsByYear W21083778562018 @default.
• W2108377856 countsByYear W21083778562023 @default.
• W2108377856 crossrefType "journal-article" @default.
• W2108377856 hasAuthorship W2108377856A5005477757 @default.
• W2108377856 hasAuthorship W2108377856A5008539103 @default.
• W2108377856 hasAuthorship W2108377856A5009238442 @default.
• W2108377856 hasAuthorship W2108377856A5038895323 @default.
• W2108377856 hasAuthorship W2108377856A5085069824 @default.
• W2108377856 hasBestOaLocation W21083778561 @default.
• W2108377856 hasConcept C104317684 @default.
• W2108377856 hasConcept C126322002 @default.
• W2108377856 hasConcept C134018914 @default.
• W2108377856 hasConcept C142724271 @default.
• W2108377856 hasConcept C169760540 @default.
• W2108377856 hasConcept C178790620 @default.
• W2108377856 hasConcept C185592680 @default.
• W2108377856 hasConcept C188053792 @default.
• W2108377856 hasConcept C2776415932 @default.
• W2108377856 hasConcept C2776538271 @default.
• W2108377856 hasConcept C2776694393 @default.
• W2108377856 hasConcept C2777093970 @default.
• W2108377856 hasConcept C2779280383 @default.
• W2108377856 hasConcept C2779651940 @default.
• W2108377856 hasConcept C3018436504 @default.
• W2108377856 hasConcept C41625074 @default.
• W2108377856 hasConcept C529278444 @default.
• W2108377856 hasConcept C529295009 @default.
• W2108377856 hasConcept C537181965 @default.
• W2108377856 hasConcept C55493867 @default.
• W2108377856 hasConcept C555293320 @default.

• next