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- W2108388539 abstract "Prostate cancer (CaP) is one of the most prevalent cancers worldwide and the incidence and mortality rates have been rapidly increasing in recent years in Taiwan. Therefore, it is important to development anti-cancer therapy. In this study, KHC-4 was identified from 2-phenyl-4-quionolone derivatives in human prostate cancer cells and as a potential antitumor agent. In this study, we have identified KHC-4 induced apoptosis effects in castration-resistant prostate cancer DU145 cells, and the IC50 value of KHC-4 was 0.1 μM. KHC-4 suppressed the survival signaling p-PI3K and p-Akt and protein levels of BeI-2 and Bel-xL, upregulated Bax, cytochrome c and caspase 8/9 and induced apoptosis by mitochondrial-dependent pathway. In JC-1 assay monitored the loss of membrane potential in KHC-4 treatments. TUNEL assay results showed DNA fragmentation in KHC-4 induced apoptosis. We concluded that KHC-4 exerted anti-tumor effects in DU145 cells by induction of apoptosis." @default.
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- W2108388539 date "2014-04-30" @default.
- W2108388539 modified "2023-09-26" @default.
- W2108388539 title "Induction of Apoptosis in Human DU145 Prostate Cancer Cells by KHC-4 Treatment" @default.
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- W2108388539 doi "https://doi.org/10.4077/cjp.2014.bab187" @default.
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